Hiperurisemia merupakan suatu kondisi berlebihnya kadar asam urat dalam darah. Hal ini dapat terjadi karena adanya kelebihan produksi asam urat dan kekurangan ekskresi asam urat, yaitu ditandai dengan kadar asam urat yang tinggi (> 7 mg/ dL). Jika hal tersebut terjadi secara terus-menerus maka akan terjadi gout arthritis. Di Arboretum Garut Terdapat banyak tanaman yang dapat digunakan sebagai antihiperurisemia seperti sirsak (Annona muricata L.), kayu manis (Cinnamomum burmanii), temu putih (Curcuma zedoaria), jamblang (Syzigium cumini), kersen (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), dan salam (Syzigium polyanthum). Review jurnal ini membahas aktivitas antihiperurisemia beberapa tanaman yang berada di Arboretum Garut. Metode yang digunakan yaitu studi literatur beberapa jurnal yang didapat melalui situs google scholar, sciencedirect, Elsevier, dan sebagainya. Hasil yang didapat dari beberapa tanaman tersebut memiliki aktivitas antihiperurisemia dan tanaman yang memiliki persentase penurunan asam urat terbesar yaitu daun S. polyanthum dengan nilai persentase penurunan asam urat sebanyak 79,35%. Daun S. polyanthum memiliki potensi antihiperurisemia paling baik, sehingga perlu dikembangkan lebih banyak di Arboretum Garut. Kata Kunci: Arboretum, Asam Urat, Gout, Hiperurisemia, Tanaman Obat Hyperuricemia is a condition of excessive levels of uric acid in the blood. This can occur due to an overproduction of uric acid and a lack of uric acid excretion, which is characterized by high uric acid levels (> 7 mg / dL). If it happens continuously, gout arthritis will occur. In Garut Arboretum, there are many plants that can be used as antihyperuricemia such as soursop (Annona muricata L.), cinnamon (Cinnamomum burmanii), white turmeric (Curcuma zedoaria), java plum (Syzigium cumini), cotton candy berry (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), and indian baywatch (Syzigium polyanthum). This journal review discusses the antihyperuricemia activity of several plants in Garut Arboretum. The method used is a literature study of several journals obtained from the google scholar site, sciencedirect, Elsevier, etc. The results show that several plants have antihyperuricemia activity and among those plants the S. polyanthum) have the highest reducing effect on blood uric acid with the reducing percentage of 79.35%. The leaves of S. polyanthum plant have the best potential for antihyperuricemia, so this plant is suggested to be developed in the Garut Arboretum.
Hyperuricemic is a condition in which uric acid level in blood exceeds its normal level. Empirically, African leaves (Vernonia amygdalina Delile.) were used to treat diabetic, hypercholesterolemic, fever, hypertension and hyperuricemic by drinking boiled water of African leaves. This in vivo study was performed to determine antihyperuricemic activity of ethanolic extract of African leaves on male mice using the POCT (Point of Care Testing) method. Suspension combination of melinjo and chicken liver juice were used as hyperuricemic inductor. It is given orally for consecutive 9 days and the uric acid level were tested on day 1, 3, 6, and 9. The results showed that the ethanolic extract of African leaves (Vernonia amygdalina Delile.) at dosage 100, 200, and 400 mg/KgBW had a significantly different antihyperuricemic activity against negative control.
<p>Obesity prevalence has increased in recent years and has caused serious health problems. This research was carried out to obtain alternative antiobesity therapy with more minimal side effects. Antiobesity activity of rose apple (Syzygium jambos (L.) Alston) leaves on female Wistar rats induced by high carbohydrate food for 45 days and subcutaneously injection of MSG 2 g/kgbw. Extraction was carried out using maceration method 96% ethanol. The test parameters observed were body weight, food intake, stool consistency and weight, liver and abdominal fat tissue weight. The results showed that high carbohydrate food and monosodium glutamate could induce obesity. Ethanol extract of rose apple leaves at doses of 25, 50 and 100 mg/kgbw body weight had antiobesity activity by inhibiting body weight gain significantly compased to positive control group (p<0.05). The highest antiobesity effect was shown by the ethanol extract of rose apple leaves at a doses of 50 mg/kgbw with % inhibition of body weight gain of 169.3% to positive control group. Ethanol extract of rose apple leaves may reduce appetite, but didn’t have laxative effect and couldn’t reduce fat deposits in the liver and abdominal fat tissue.</p>
Diabetes mellitus is a metabolic disease characterized by hyperglycemia. This disease occurs due to abnormalities in insulin secretion, insulin work or both. Plants from the myrtaceae family that have been used traditionally as medicine and scientifically known to have various anti-inflammatory, anti-cancer, anti-diarrheal, antibacterial and antidiabetic activities. This review aims to provide information and efforts in the treatment of diabetes from several plants in the Myrtaceae family. The method used in this review is a literature review from various journals published online and I will discuss 8 plants from the myrtaceae family that are induced by alloxan. From the results it is known that of the 8 plants of the myrtaceae family that have been tested using alloxan induction has antidiabetic activity. Syzygium Polyanthum (Wight) is the most potential candidate in reducing blood glucose levels.
Kanker prostat merupakan merupakan kanker yang paling umum diderita oleh pria selama 2016, kasus baru pada penderita kanker prostat sudah diperkirakan sebanyak 180.890 dan kasus kematian 26.120 kasus. Terapi yang sering digunakan pada penderita kanker prostat ini salah satunya adalah kemoterapi. Kemoterapi dapat menyebabkan senyawa antikanker tidak sensitif, karena terjadi resistensi sel kanker. Maka dari itu, diperlukan pula metode alternatif pengobatan tradisional atau herbal. Dalam terapi kanker, penggunan tanaman herbal dinilai memiliki efek samping yang lebih kecil dibandingkan dengan terapi menggunakan obat-obat kimia. Daun pepaya (Carica papaya L.) merupakan salah satu tumbuhan yang telah diteliti memiliki aktivitas sitotoksik MiaPaca-2 dan ASPC-1. Dalam penelitian ini, dilakukan uji sitotoksisitas ekstrak etanol dan fraksi-fraksi daun pepaya (Carica papaya L.) terhadap sel kanker DU 145 untuk mengetahui aktivitas antikanker dengan menggunakan metode MTT Assay. Hasil uji sitotoksisitas terhadap sel kanker prostat DU 145 menunjukan esktrak etanol, fraksi n-heksan, fraksi etil asetat, dan fraksi air dengan berbagai konsentrasi 31.25, 62.5, 125, 250, dan 500 µg/mL.Fraksi N-heksan memiliki nilai IC50 sebesar 2,80 µg/mL dengan kategori sangat aktif. Hasil aktivitas sitotoksik tersebut dibuktikan dari hasil penafisan fitokimia dari daun pepaya. Metabolit sekunder yang bersifat nonpolar seperti alkaloid pada penafisan fitokimia memperoleh hasil positif. Hal ini membuktikan bahwa alkaloid (carpaine) berkhasiat melawan kanker. Sedangkan pada fraksi air dengan nilai IC50 sebesar 398 µg/mL, fraksi etil asetat sebesar 134 µg/mL dan ekstrak etanol daun pepaya memiliki nilai IC50 sebesar 151 µg/mL bersifat cukup aktif terhadap sel DU 145.
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