THE ANTIOBESITY ACTIVITY OF ETHANOL EXTRACT OF ROSE APPLE (Syzygium jambos (L.) Alston) ON FEMALE WISTAR RATS

Abstract

<p>Obesity prevalence has increased in recent years and has caused serious health problems. This research was carried out to obtain alternative antiobesity therapy with more minimal side effects. Antiobesity activity of rose apple (Syzygium jambos (L.) Alston) leaves on female Wistar rats induced by high carbohydrate food for 45 days and subcutaneously injection of MSG 2 g/kgbw. Extraction was carried out using maceration method 96% ethanol. The test parameters observed were body weight, food intake, stool consistency and weight, liver and abdominal fat tissue weight. The results showed that high carbohydrate food and monosodium glutamate could induce obesity. Ethanol extract of rose apple leaves at doses of 25, 50 and 100 mg/kgbw body weight had antiobesity activity by inhibiting body weight gain significantly compased to positive control group (p<0.05). The highest antiobesity effect was shown by the ethanol extract of rose apple leaves at a doses of 50 mg/kgbw with % inhibition of body weight gain of 169.3% to positive control group. Ethanol extract of rose apple leaves may reduce appetite, but didn’t have laxative effect and couldn’t reduce fat deposits in the liver and abdominal fat tissue.</p>

Potential Role of Centella asiatica and Sauropus androgynus in High-Fat and High-Fructose Diet-Induced-Obesity Animal Model

“…There were no significant differences between the negative and positive control groups, indicating that the HFHF diet for 28 days did not affect the organ index. Several antiobesity studies require up to 45 days of treatment time in modeling obesity test animals (Qowiyyah et al, 2020).…”