Aktivitas Antihiperurisemia Ekstrak Etanol Daun Afrika (Vernonia amygdalina Delile.) pada Mencit Putih Galur Swiss Webster yang Diinduksi Melinjo dan Hati Ayam

Abstract

Hyperuricemic is a condition in which uric acid level in blood exceeds its normal level. Empirically, African leaves (Vernonia amygdalina Delile.) were used to treat diabetic, hypercholesterolemic, fever, hypertension and hyperuricemic by drinking boiled water of African leaves. This in vivo study was performed to determine antihyperuricemic activity of ethanolic extract of African leaves on male mice using the POCT (Point of Care Testing) method. Suspension combination of melinjo and chicken liver juice were used as hyperuricemic inductor. It is given orally for consecutive 9 days and the uric acid level were tested on day 1, 3, 6, and 9. The results showed that the ethanolic extract of African leaves (Vernonia amygdalina Delile.) at dosage 100, 200, and 400 mg/KgBW had a significantly different antihyperuricemic activity against negative control.

Uji aktivitas antihiperurisemia ekstrak daun kopasanda (Chromolaena Odorata (L.) R.M.King & H.Rob terhadap mencit putih jantan (Mus Musculus L.) yang diinduksi kalium oxonat

“…Pada penelitian ini, penurunan kadar asam urat yang lebih baik terjadi ketika menggunakan dosis ekstrak yang lebih tinggi, yaitu 400 mg per berat badan. Dosis yang lebih tinggi menyebabkan adanya lebih banyak senyawa aktif atau metabolit sekunder dalam ekstrak, sehingga dapat menurunkan kadar asam urat dengan lebih baik dan dalam waktu yang lebih cepat (Nuari, Renggana, Yuniar, Novitasari, & Lulu, 2021).…”

Antioxidant activity and inhibition of α-glucosidase from extract and fraction of leaves and stems of Vernonia amygdalina

“…Previous studies reported that Vernonia amygdalina has several secondary metabolites, which include alkaloids, phenols, anthraquinones, cardiac glycosides, tannins, terpenoids, saponins, and terpenoids [3]- [5]. Previous studies have also reported that Vernonia amygdalina has several biological activities such as antihyperuricemia [6], antibacterial and antimicrobial [4], antioxidant [7], and inhibition of α-glucosidase enzyme [8].…”

Percentage of internal organs of broiler chickens given Vernonia amygdalina flour feed additives

“…African leaf ethanol extract contains flavonoids, saponins, and tannins [11] and can be used for antihypertensives the leaves are highly IOP Publishing doi:10.1088/1755-1315/1107/1/012069 2 nutritious and have antioxidants [12]. People use it as a medicine for diabetes, hypercholesterolemia, fever, hypertension, and gout [13].…”