It is well known that skin aging results from an intrinsic process involving genetic background and an extrinsic process influenced by environmental factors. 1 Many anti-aging cosmetic products are used to prevent and treat it, 2 while others, which are minimally invasive, safe, and effective, have not been so widespread, perhaps due to their characteristics and application method. One example is the intradermal injections with platelet-rich plasma (PRP), 3 whose results are significant, with high patient satisfaction, and without serious adverse effects. 4 A novelty related to these products is the use of
Purpose: To evaluate the efficacy and safety of photothermal bioactivated plateletrich plasma for reducing laxity in facial rejuvenation in patients not eligible for other aesthetic treatments due to several comorbidities. Methods:A prospective, nonrandomized study was conducted. Efficacy was assessed through a satisfaction scale and the Facial Laxity Rating Scale. Safety assessments were based on the data of all adverse events and the visual analog pain scale.Results: Seven patients with a mean age of 51 (standard deviation [SD] 7.46, range 42-63) were included. In six patients (85.7%), the treatment was applied to the face and neck, and in one patient (14.3%), only to the lower half of the face and neck. The physician's perception of laxity decreased, and the procedure was not complex. Patients' and physician satisfaction increased as the study progressed. Adverse effects were not serious and resolved without sequelae. The patients' pain perceived during the treatment was mild in most cases. Conclusion:The photothermal bioactivated platelet-rich plasma injections were a safe and effective treatment for facial laxity in patients not eligible for other procedures, providing good satisfaction.
Background Different causes may be responsible for delayed inflammatory reactions after hyaluronic acid injections, among them several mechanisms of SARS‐CoV‐2. Aims The study's objective was to assess the percentage of adverse reactions after hyaluronic acid injections in a cohort of adult patients with a test for SARS‐CoV‐2 or vaccinated during the COVID‐19 pandemic. Patients/Methods An observational, retrospective, comparative, multi‐center, non‐interventional in a real‐life setting study was carried out with patients treated with facial injections of hyaluronic acid from May to September 2021, with a test to discard SARS‐COV 2 or that had been vaccinated. Results Sixty‐three patients were included. Seven (11.1%) were vaccinated patients without a test for SaRS‐CoV‐2 and 56 (88.9%) with antigenic or PCR screening tests (18 [32.1%] negative and 39 [69.6%] positives for COVID‐19). The mean age was 51.3 (SD 12.71; range 23–70), and 57 (90.5%) were female. Twenty‐three patients (36.5%) had a history of adverse events with hyaluronic acid injections. During the study, 15 adverse events were reported; 11 patients (73.3%) had a history (p = 0.0018); two patients (13.3%) had been vaccinated; 13 (86.7%) had performed a SARS‐CoV2 test (six [46.2%] negatives, and seven [53.8%] with a positive result; p = 0.5969). All adverse study events were resolved, and none had sequelae. Conclusion Adverse events after hyaluronic acid facial injections were higher among patients with a history but not among those diagnosed with COVID‐19. The new scenario related to COVID‐19 infections or vaccinations would require readapting criteria for applying hyaluronic acid injections.
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