Efficacy and safety of photothermal‐bioactivated platelet‐rich plasma for facial rejuvenation

Abstract

It is well known that skin aging results from an intrinsic process involving genetic background and an extrinsic process influenced by environmental factors. 1 Many anti-aging cosmetic products are used to prevent and treat it, 2 while others, which are minimally invasive, safe, and effective, have not been so widespread, perhaps due to their characteristics and application method. One example is the intradermal injections with platelet-rich plasma (PRP), 3 whose results are significant, with high patient satisfaction, and without serious adverse effects. 4 A novelty related to these products is the use of

Efficacy of photo‐thermal‐bioactivated platelet‐rich plasma for skin biostimulation in patients not eligible for other medical‐aesthetic treatment: A pilot study

“…18 Other studies have shown that the thermoactivated PRP, maintaining high quality, showed more physiological characteristics than PRP without additives. 19 A comparative study with PTBA-PRP in the aging facial treatment following the same preparation protocol and device of our study, 16 rated skin improvement as good as 60%, compared to the one obtained with PRP without PTBA. None of them reported severe AEs and or technical issues.…”

“…PRP therapy is generally well tolerated and suitable for all phototypes 15 and even is used for treating patients with various dermatological conditions and concerns. Photothermal‐bioactivated PRP (PTBA‐PRP) is currently being used for facial rejuvenation with excellent results 16 …”

“…Photothermal-bioactivated PRP (PTBA-PRP) is currently being used for facial rejuvenation with excellent results. 16 The study's objective was to evaluate the efficacy and safety of photothermal bioactivated platelet-rich plasma for reducing laxity in facial rejuvenation in patients not eligible for other aesthetic treatments due to several comorbidities.…”

The Biological Role of Platelet Derivatives in Regenerative Aesthetics

“…Skin aging is influenced by intrinsic factors, such as genetic background and chronological age, as well as extrinsic factors, such as exposure to ultraviolet radiation, trauma, air pollution, alcohol consumption, nutritional issues, smoking, and reactive oxygen species causing DNA damage. These factors contribute to decreased or hyperexpression in melanocytes, reduced fibroblast activity, and diminished collagen and elastin synthesis, leading to dermal disruption and the dysregulation of the stem cell population responsible for tissue repair [ 60 , 61 ]. Subsequent skin changes involve hyper- or hypopigmentation, skin laxity, and the development of both superficial and deep wrinkles, significantly impacting self-image and social acceptance [ 62 ].…”