Efficacy of photo‐thermal‐bioactivated platelet‐rich plasma for skin biostimulation in patients not eligible for other medical‐aesthetic treatment: A pilot study

Abstract

Purpose: To evaluate the efficacy and safety of photothermal bioactivated plateletrich plasma for reducing laxity in facial rejuvenation in patients not eligible for other aesthetic treatments due to several comorbidities. Methods:A prospective, nonrandomized study was conducted. Efficacy was assessed through a satisfaction scale and the Facial Laxity Rating Scale. Safety assessments were based on the data of all adverse events and the visual analog pain scale.Results: Seven patients with a mean age of 51 (standard deviation [SD] 7.46, range 42-63) were included. In six patients (85.7%), the treatment was applied to the face and neck, and in one patient (14.3%), only to the lower half of the face and neck. The physician's perception of laxity decreased, and the procedure was not complex. Patients' and physician satisfaction increased as the study progressed. Adverse effects were not serious and resolved without sequelae. The patients' pain perceived during the treatment was mild in most cases. Conclusion:The photothermal bioactivated platelet-rich plasma injections were a safe and effective treatment for facial laxity in patients not eligible for other procedures, providing good satisfaction.

Evaluation of the effects of adding an adipose tissue‐derived stromal vascular fraction to platelet‐rich plasma injection in the treatment of androgenetic alopecia: A randomized clinical trial

“…12 PRP functions via the upregulation of β-catenin and fibroblast growth factor-7 (FGF-7) signaling, as well as anti-apoptotic effects (Bcl2 release). 12,13 SVF secretes insulin-like growth factor 1 (IGF-1), platelet-derived growth factor (PDGF), and anti-inflammatory cytokines. Thus, SVF and PRP are assumed to stimulate hair follicle proliferation and inhibit apoptosis.…”