No abstract

Background: Modern biology has shifted from "one gene" approaches to methods for genomic-scale analysis like microarray technology, which allow simultaneous measurement of thousands of genes. This has created a need for tools facilitating interpretation of biological data in "batch" mode. However, such tools often leave the investigator with large volumes of apparently unorganized information. To meet this interpretation challenge, gene-set, or cluster testing has become a popular analytical tool. Many gene-set testing methods and software packages are now available, most of which use a variety of statistical tests to assess the genes in a set for biological information. However, the field is still evolving, and there is a great need for "integrated" solutions.

This paper is concerned with paraphrase detection. The ability to detect similar sentences written in natural language is crucial for several applications, such as text mining, text summarization, plagiarism detection, authorship authentication and question answering. Given two sentences, the objective is to detect whether they are semantically identical. An important insight from this work is that existing paraphrase systems perform well when applied on clean texts, but they do not necessarily deliver good performance against noisy texts. Challenges with paraphrase detection on user generated short texts, such as Twitter, include language irregularity and noise. To cope with these challenges, we propose a novel deep neural network-based approach that relies on coarse-grained sentence modeling using a convolutional neural network and a long short-term memory model, combined with a specific fine-grained word-level similarity matching model. Our experimental results show that the proposed approach outperforms existing state-of-the-art approaches on user-generated noisy social media data, such as Twitter texts, and achieves highly competitive performance on a cleaner corpus.

No abstract

Key Points Question What is the external validity of a deep learning–based method to predict cerebral palsy (CP) based on infants’ spontaneous movements at 9 to 18 weeks’ corrected age? Findings In this prognostic study of 557 infants with a high risk of perinatal brain injury, a deep learning–based method for early prediction of CP had sensitivity of 71%, specificity of 94%, positive predictive value of 68%, and negative predictive value of 95%. Prognosis of CP based on the deep learning–based method was associated with later functional level and CP subtype in children with CP. Meaning This study’s findings suggest that deep learning–based assessments could support early detection of CP in infants at high risk.