Key Points Question What is the external validity of a deep learning–based method to predict cerebral palsy (CP) based on infants’ spontaneous movements at 9 to 18 weeks’ corrected age? Findings In this prognostic study of 557 infants with a high risk of perinatal brain injury, a deep learning–based method for early prediction of CP had sensitivity of 71%, specificity of 94%, positive predictive value of 68%, and negative predictive value of 95%. Prognosis of CP based on the deep learning–based method was associated with later functional level and CP subtype in children with CP. Meaning This study’s findings suggest that deep learning–based assessments could support early detection of CP in infants at high risk.

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