A transition-metal-free coupling
reaction of aryne, DMSO, and activated
alkyne for the synthesis of 2-[(o-methylthio)aryloxy]-substituted
dialkyl maleates is reported. This cascade process is associated with
several bond cleavage as well as bond formation reactions in one pot.
One of our synthesized maleates has been unambiguously established
by single-crystal XRD studies. This methodology allows preparation
of trisubstituted vinyl ethers with excellent stereospecificity.
A transition-metal free synthetic strategy for the direct synthesis of ortho-methylthio allyl and vinyl ethers via cascade three-component coupling of aryne, activated alkene and DMSO.
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