A transition-metal-free coupling
reaction of aryne, DMSO, and activated
alkyne for the synthesis of 2-[(o-methylthio)aryloxy]-substituted
dialkyl maleates is reported. This cascade process is associated with
several bond cleavage as well as bond formation reactions in one pot.
One of our synthesized maleates has been unambiguously established
by single-crystal XRD studies. This methodology allows preparation
of trisubstituted vinyl ethers with excellent stereospecificity.
This review provides a collective and informative discussion on the potential applications of Kobayashi's aryne precursor as a versatile building block for the synthesis of polycyclic aromatic hydrocarbons.
A transition-metal free synthetic strategy for the direct synthesis of ortho-formyl substituted allyl aryl ethers and 2H-chromen-2-ol derivatives via a cascade three-component coupling of arynes, activated alkene and N,N-dimethylformamide.
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