A copper(II)-catalyzed borylation
of alkyl halides with bis(pinacolato)diboron
(B2pin2) has been developed, which can be carried
out in air, providing a wide range of primary, secondary, and some
tertiary alkylboronates in high yields. A variety of functional groups
are tolerated and the protocol is also applicable to unactivated alkyl
chlorides (including 1,1- and 1,2-dichlorides). Preliminary mechanistic
investigations show that this borylation reaction involves one-electron
processes.
Mixed-ligand complexes of copper(ii) with thienoyltrifluoroacetonate, 2,2′-bipyridine, 1,10-phenanthroline, and tetramethylethylenediamine, associated with counter ions such as Cl− and NO3 have been synthesized and characterized.
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