Antidiabetes, antimicrobial and antioxidant studies of mixed β-diketone and diimine copper(II) complexes

Omoregie, Helen Oluwatola; Yusuf, Tunde L.; Oladipo, Segun D.; Olofinsan, Kolawole; Kassim, Mohammed B.; Yousuf, Sammer

doi:10.1016/j.poly.2022.115738

Cited by 11 publications

(14 citation statements)

References 57 publications

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“…All complexes were various shades of green in colour, except [Cu(TTA)(tmen)]NO 3 which was dark blue in colour. The molar conductivities of the complexes are low with Λ m values in the range of 34–47 ohm −1 cm 2 mol −1 , which suggest that they are non-electrolytes 48–50 except [Cu(TTA)(tmen)]NO 3 which is a 1 : 1 electrolyte.…”

Section: Resultsmentioning

confidence: 99%

“…62,64 Hence, a minor shi to higher frequency of the ligand eld spectral band in a coordinating solvent such as methanol relative to a non-coordinating solvent for copper(II) species in solution is indicative of a probable transformation from vecoordinate square pyramidal copper(II) environment to sixcoordinate environment upon coordination of such solvents as methanol. 49,50,63 Thus, complexes 1-5 have square-pyramidal geometry due to higher energy shis in methanol relative to chloroform. The intraligand p-p* and ligand to metal charge transfer (LMCT) transitions are observed in the 28 249-50 000 cm À1 region for the synthesized complexes.…”

Section: Electronic Spectramentioning

confidence: 99%

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Mixed-ligand complexes of copper(ii) with thienoyltrifluoroacetonate and nitrogen containing ligands: synthesis, structures, antimicrobial activity, cytotoxicity, Hirshfeld surface analysis and DFT studies

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Electronic Spectramentioning

confidence: 99%

Mixed-ligand complexes of copper(ii) with thienoyltrifluoroacetonate and nitrogen containing ligands: synthesis, structures, antimicrobial activity, cytotoxicity, Hirshfeld surface analysis and DFT studies

et al. 2022

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“…The successful synthesis of SBs was confirmed from formation of new peaks in FTIR in the range of 1615.91-1649.19 cm À 1 for the À HC=N group and the vanishing of À NH 2 duplet (3500-3300 cm À 1 ) and a strong peak of C=O (1740-1720 cm À 1 ). The structure of SBs was elucidated by 1 HNMR spectroscopy. The NH 2 peak at σ = 4.77 ppm disappears due to imine formation.…”

Section: Synthesis and Characterization Of Smpr Sbsmentioning

confidence: 99%

“…Researchers are investigating new potential compounds to treat such complications. [1] Microbe-based infections are one of the leading causes of death around the world. A significant problem is the scarcity of antibiotics to treat illnesses and the emergence of resistance to previous antimicrobials.…”

Section: Introductionmentioning

confidence: 99%

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Biological Activities, DFT and Molecular Docking Studies of Novel Schiff Bases Derived from Sulfamethoxypyridazine

Wajid,

Uzair,

Muhammad

et al. 2024

ChemistrySelect

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The present study reported the synthesis and biological activities of sulfamethoxypyridazine (SMPR) Schiff bases (SBs) with different aromatic aldehydes. The antimicrobial potential of SBs against various pathogenic strains (S. epidermidis, E. coli, S. agalactiae, S. aureus, S. typhi, K. pneumoniae, C. albicans, and C. tropicalis) was explored by disc diffusion method. The antidiabetic potential was monitored by inhibition of α‐amylase, α‐glucosidase, and anti‐inflammatory activity was studied by protein denaturation assay. The binding of protein with SBs was determined by MOE docking. The synthesized SBs reveal significant antimicrobial potential against all strains (p values<0.0001) better than the parent drug SMPR but less than amoxicillin. The synthesized SBs exhibited reasonable inhibition potential against α‐glucosidase, α‐amylase, and anti‐inflammatory activity. The derivative 10 a depicted antioxidant (IC50 value 12.18 μg/mL) and anti‐inflammatory (IC50 value 49.37 μg/mL) even better than standard ascorbic acid and diclofenac sodium (IC50 values 49.92 and 123.81 μg/mL), respectively. Molecular docking results revealed that synthesized SBs have good binding affinities towards different receptor proteins and results support our experimental results. The electronic properties have been calculated using density function theory (DFT) to determine the chemical reactivity of studied compounds. The low energy gap between Frontier Molecular Orbitals (FMOs) revealed the significant chemical reactivity of compounds 8 a and 10 a, among other compounds.

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An experimental and computational studies, evaluating the in vitro antidiabetic and antioxidant activity, in silico prediction ADMET properties of 5‐chloro‐1H‐benzimidazole and its newly synthesized silver(I) complex

Kucuk,

Celik,

Yurdakul

et al. 2024

Applied Organom Chemis

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In this research, a new Ag(I) complex, namely, [Ag(5‐chloro‐1H‐benzimidazole)2(NO3)], has been synthesized using the benzimidazole‐based ligand 5‐chloro‐1H‐benzimidazole (5ClBZ). Ag(I) complexes were characterized by elemental analysis, UV‐Vis, FT‐IR, and 1H NMR spectroscopy, and DFT analysis was used. The free ligand and its Ag(I) complexes were tried for their biochemical properties, including antioxidant and antidiabetic properties. To study the molecular structures of the title compounds, in silico ADME/Tox research was performed on the newly made complex and free ligand. The empirical guidelines relating to ADME were utilized to conduct molecular docking simulations and in‐depth drug‐likeness profiling. This was carried out to validate the conclusions and identify exact binding interactions. Based on the study's findings, it has been determined that these new compounds have significant potential as powerful therapeutic agents for controlling antioxidant and antidiabetic activities.

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Antidiabetes, antimicrobial and antioxidant studies of mixed β-diketone and diimine copper(II) complexes

Cited by 11 publications

References 57 publications

Mixed-ligand complexes of copper(ii) with thienoyltrifluoroacetonate and nitrogen containing ligands: synthesis, structures, antimicrobial activity, cytotoxicity, Hirshfeld surface analysis and DFT studies

Mixed-ligand complexes of copper(ii) with thienoyltrifluoroacetonate and nitrogen containing ligands: synthesis, structures, antimicrobial activity, cytotoxicity, Hirshfeld surface analysis and DFT studies

Biological Activities, DFT and Molecular Docking Studies of Novel Schiff Bases Derived from Sulfamethoxypyridazine

An experimental and computational studies, evaluating the in vitro antidiabetic and antioxidant activity, in silico prediction ADMET properties of 5‐chloro‐1H‐benzimidazole and its newly synthesized silver(I) complex

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