FOWL PLAGUE is caused by an infectious filtrable virus and is characterized by high mortality among chickens. Although the disease has not occurred in the United States since 1929, it has been considered enzootic chiefly in eastern Europe, the Mediterranean basin, Egypt, and Asia. The disease has often been confused with that caused by the virulent form of Newcastle disease virus. In 1959, slightly more than a month after he returned from a 2-month trip abroad, a 46-yearold white man with clinically diagnosed infec¬ tious hepatitis was hospitalized. He had been generally healthy during visits to Japan,
Antibody titers to a group of viral antigens have been determined in sera from patients with systemic lupus erythernatosus (SLE), control groups with inflammatory diseases and normals. Mean titers in SLE sera for all viruses tested were significantly greater than in four control groups, but not greater than in active tuberculosis, both by the complement-fixation (CF) and hemagglutination-inhibition (HI) methods. By the CF method, only measles virus showed significantly higher titers in SLE than in all control groups; by the HI method, measles antibody titers were higher in SLE than in all groups but tuberculosis. There was no correlation between antibody titers and gammaglobulin levels. The results indicated a moderate though variable overall hypereactivity in SLE to the viral antigens tested.Interest has grown recently in the possibility that the etiology of SLE is viral in nature. One reason for this interest has been the observation of cytoplasmic myxovirus-like tubular structures in the tissues of patients with SLE. These have been most commonly reported (1-5) in kidney biopsies of patients with lupus nephritis. The cytoplasmic structures described are simi-
Antibodies against mumps virus have been studied by using immunoglobulin class-specific indicators labeled with 125I in the radioimmunoassay (RIA) procedure. The immunoglobulins in paired acute and convalescent sera were allowed to react with mumps virus in a solid-phase RIA system. Class-specific immunoglobulin indicators (anti-immunoglobulin M [IgM] and anti-immunoglobulin G [IgG]) labeled with 121I revealed that immunoglobulins of early antisera were preponderantly IgM, whereas immunoglobulins of late antisera were predominantly IgG. These indicators detected antibodies of the early (IgM) and late (IgG) phases of the immune response. These findings are consistent with the classical temporal order of appearance of 198 (IgM) and 7s (IgG) globulins. Specificity of these indicators for reacting with fractionated 7s and 198 globulins is also presented. Mumps virus RIA obtained with anti-IgG correlated well with conventional serological data obtained by neutralization and hemagglutination inhibition, but most strongly with complement-fixation data. In addition, antibody bound by solid phase was capable of distinguishing between related antigens of the myxovirus group.
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