The antiviral activity of a number of fractions of poly(acry1ic acid)s and poly(methacry1ic acid)s with different tacticities, different molecular weights and molecular weight distributions has been investigated. Isotactic poly(acry1ic acid)s are essentially more antiviral active in the whole area of efficacy than the atactic ones. Independent of the tacticity poly(acry1ic acid)s with molecular weights smaller than 5000 show no significant effects, polymers with molecular weights greater than 25000 are toxic in the used doses. The optimum of efficacy is between 6000 and 15000. Isotactic poly(acry1ic acid)s with narrow molecular weight distributions are more active than those with broad distributions. The atactic poly(acry1ic acid)s with lower efficacy do not show this relationship. Atactic poly(methacry1ic acid)s are not antiviral active in vivo compared with untreated controls. Isotactic ones have a just detectable efficacy which is essentially lower than the activity of the atactic poly(acry1ic acid)s.

ZUSAMM ENFASSUNG :Es wurden zwei Methacrylatmonomere (3 und 6 ) dargestellt, welche die 1 -Adamantylamino-Gruppe mit verschiedenen Spacergruppen enthalten. Die neuen Monomeren wurden mit 2-Methylsulfinylathylmethacrylat zu wasserloslichen Produkten copolymerisiert. Die Copolymeren mit 1-Adamantylamino-Gruppen sowie eine Modellsubstanz ohne Adamantyl-Gruppe wurden in vitro und in vivo auf ihre Wirkung gegen InfluenzaViren untersucht. SUMMARY:Two methacrylate monomers (3 and 6) containing 1-adamantylamino groups with different spacer gioups were prepared. The new monomers were copolymerized with 2-methylsulfinylethyl methacrylate to yield water soluble products. The copolymers containing the 1 -adamantylamino group and a model compound without adamantyl groups were tested in vitro and in vivo against influenca virus infections.