Pharmakologisch aktive polymere, 9. Synthese und untersuchung makromolekularer derivate des 1‐adamantanamins

A number of acryl and methacryl derivatives of different sulfanilamides (la-I) were prepared and polymerized. The fixation of the sulfonamide to the polymerizable group was carried out directly, using the acryl-and methacrylamides, and by means of spacer groups, to favour the enzymatic or hydrolytic release of the drug moiety. Selected sulfonamide types of different pKA values were used, and the pH-dependant solubility of the corresponding polymers was studied.The monomeric acryloyl and methacryloyl sulfonamides were homopolymerized radically by AIBN. Fordistributionstudiespolysulfadiazineacrylamide, ''C-labelledin the main chain (W), was synthesized. Copolymerization with 2-methylsulfinylethy1 methacrylate (Sa) yielded water soluble polymers of lower toxicity. Eventually biodegradable polymers containing sulfonamide units in the backbone were obtained by anionic polymerization of acryloyl and methacryloyl sulfanilamide.The new monomers and polymers were characterized by elemental analysis, IR-and NMR-spectroscopy, pyrolysis mass spectrometry, and hydrolytic degradation. ZUSAMMENFASSUNG:Eine Reihe von Acryl-und Methacrylderivaten verschiedener Sulfanilamide (la-I) wurde hergestellt und polymerisiert. Die Fixierung der Sulfonamide erfolgte direkt, als Acrylund Methacrylamid, und mit Hilfe von Spacergruppen, zur Aktivierung der enzymatischen oder hydrolytischen Abspaltung des Pharmakons. Es wurden Sulfonamide mit verschiedenen pKs-Werten verwendet und die pH-abhangige Loslichkeit der entsprechenden Polymeren untersucht.Die monomeren Acryloyl-und Methacryloylsulfonamide wurden radikalisch mit AIBN homopolymerisiert. Zur Untersuchung der Korperverteilung wurde ' 4C hauptkettenmar-*) kiertes Polysulfadiazinacrylamid (2e') dargestellt. Durch Copolymerisation mit 2-Methylsulfinylathylmethacrylat (5a) wurden wasserlosliche Polymere mit geringerer Toxizitat erhalten. Eventuell biologisch abbaubare Polymere mit Sulfonamidgruppen in der Hauptkette wurden durch anionische Polymerisation von Acryloyl-und Methacryloylsulfanilamid dargestellt. Die neuen Monomeren und Polymeren wurden durch Elementaranalyse, IR-und NMR-Spektroskopie, Pyrolyse-Massenspektrometrie und hydrolytischen Abbau charakterisiert.

show abstract

Pharmacologically active polymers, 11. Polymeric sulfonamides as potential antibacterials and carriers for antitumor agents

Hofmann

Przybylski

Ringsdorf

et al. 1976

Makromol. Chem.

View full text Add to dashboard Cite

show abstract

Pharmakologisch aktive Polymere, 12. Depotformen von Chlorambucil durch kovalente Bindung an Polymere

Franzmann

Ringsdorf

1976

Makromol. Chem.

View full text Add to dashboard Cite

Recherche de télomères à activité pharmacologique potentielle, 2. Télomères de l'acide acrylique et greffage de composés hydroxylés

et al. 1981

View full text Add to dashboard Cite

Several telomers of acrylic acid with carbone tetrachloride were prepared. Their average degree of polymerization, which was between 10 and 50, was determined by several analytical methods (elemental analysis,viscosimetry, and GPC). From the kinetic equations of telomerization a relation between DP, of these telomers and the experimental conditions is established. Fixation of hydroxylic compounds through direct esterification was studied and it was found that the prepared telomers can be used as hydrosoluble carriers for drugs containing primary alcohol or phenol functions.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Pharmakologisch aktive polymere, 9. Synthese und untersuchung makromolekularer derivate des 1‐adamantanamins

Cited by 17 publications

References 18 publications

Pharmacologically active polymers, 11. Polymeric sulfonamides as potential antibacterials and carriers for antitumor agents

Pharmacologically active polymers, 11. Polymeric sulfonamides as potential antibacterials and carriers for antitumor agents

Pharmakologisch aktive Polymere, 12. Depotformen von Chlorambucil durch kovalente Bindung an Polymere

Recherche de télomères à activité pharmacologique potentielle, 2. Télomères de l'acide acrylique et greffage de composés hydroxylés

Contact Info

Product

Resources

About