Strontium has attained increasing interest in the treatment of osteoporosis due to its anabolic as well as antiresorptive activity. Knitted cellulose scaffolds with a porosity suitable to promote bone tissue ingrowth and vascularisation were doped with SrCO 3 . The in vitro bioactivity of the modified scaffolds was proven by formation of hydroxyapatite during exposure to simulated body fluid. The Sr-release kinetics during static exposure to simulated body fluid is dominated by an accelerated Sr-release in the initial state followed by a reduced release corresponding to a diffusion controlled rate. Microstructural analyses indicate that initially precipitated SrCO 3 transforms to Sr x Ca 1-x CO 3 solid solutions that subsequently serve as a template for the precipitation of bone like carbonated hydroxyapatite under conditions simulating the inorganic part of the human blood plasma.
Cellulose‐based scaffolds osteoactivated with different sodium silicate coatings (pure and bisphosphonate or strontium enriched respectively) can serve as long‐term depots for a slow drug‐release. Thus they are a promising and cost‐saving alternative to the short‐lived drug delivery systems of recombinant bone promoting proteins.
Knits made of cellulose are promising scaffolds for bone tissue engineering applications
due to their multi-scale interconnected porosity, biocompatibility and adjustable biodegradability.
The approach of this study combines the modification of cellulose with strontium to generate
scaffolds capable of forming bone like apatite during exposure to physiological solutions and the
release of strontium as an active agent, that might encourage the development of new bone tissue.
The Sr-release kinetics during static exposure to simulated body fluid is dominated by an
accelerated Sr-release in the initial state followed by a reduced release corresponding to a diffusion
controlled rate. Microstructural analyses indicate that initially precipitated SrCO3 transforms to
SrxCa1-xCO3 solid solutions that subsequently serve as a template for the precipitation of bone like
carbonated hydroxyapatite.
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