In vivo Performance of Osteoactivated Cellulose‐Based Scaffolds in Bony Critical‐Size Defects

Ponader, Sabine; Brandt, Heike; Vairaktaris, Eleftherios; Wilmowsky, Cornelius von; Göthel, Wolfgang; Lutz, Rainer; Schlegel, Karl Andreas; Neukam, Friedrich Wilhelm; Greil, Peter; Müller, Frank A.; Nkenke, Emeka

doi:10.1002/adem.200800437

Cited by 4 publications

(3 citation statements)

References 58 publications

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“…Furthermore, the graphene oxide reduced the pore diameter and eventually changed the pore morphology of the scaffolds [ 57 ]. Graphene oxide incorporated in starch nanocomposites has shown to improve the biological property [ 58 ]. The application of starch in tissue engineering, however, is minimal due to its brittleness and hydrophilicity.…”

Section: Natural Vs Synthetic Biomaterialsmentioning

confidence: 99%

Osteogenic Potential of Graphene in Bone Tissue Engineering Scaffolds

2018

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Scaffolds are physical substrates for cell attachments, proliferation, and differentiation, ultimately leading to tissue regeneration. Current literature validates tissue engineering as an emerging tool for bone regeneration. Three-dimensionally printed natural and synthetic biomaterials have been traditionally used for tissue engineering. In recent times, graphene and its derivatives are potentially employed for constructing bone tissue engineering scaffolds because of their osteogenic and regenerative properties. Graphene is a synthetic atomic layer of graphite with SP2 bonded carbon atoms that are arranged in a honeycomb lattice structure. Graphene can be combined with natural and synthetic biomaterials to enhance the osteogenic potential and mechanical strength of tissue engineering scaffolds. The objective of this review is to focus on the most recent studies that attempted to explore the salient features of graphene and its derivatives. Perhaps, a thorough understanding of the material science can potentiate researchers to use this novel substitute to enhance the osteogenic and biological properties of scaffold materials that are routinely used for bone tissue engineering.

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Section: Natural Vs Synthetic Biomaterialsmentioning

confidence: 99%

Osteogenic Potential of Graphene in Bone Tissue Engineering Scaffolds

2018

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“…GO is also incorporated in starch in order to improve its physical and biological properties. [67,75,76] GO/starch nanocomposites were produced in the form of films.…”

Section: (7 Of 22)mentioning

confidence: 99%

Graphene Oxide/Polymer‐Based Biomaterials

2017

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Since its discovery in 2004, derivatives of graphene have been developed and heavily investigated in the field of tissue engineering. Among the most extensively studied forms of graphene, graphene oxide (GO), and GO/ polymer-based nanocomposites have attracted great attention in various forms such as films, 3D porous scaffolds, electrospun mats, hydrogels, and nacre-like structures. In this review, the most actively investigated GO/ polymer nanocomposites are presented and discussed, these nanocomposites are based on chitosan, cellulose, starch, alginate, gellan gum, poly(vinyl alcohol) (PVA), poly(acrylamide), poly(e-caprolactone) (PCL), poly(lactic acid) (PLLA), poly(lactide-co-glycolide) (PLGA), gelatin, collagen, and silk fibroin (SF). The biological and mechanical performance of such nanocomposites are comprehensively scrutinized and ongoing research questions are addressed. The analysis of the literature reveals overall the great potential of GO/ polymer nanocomposites in tissue engineering strategies and indicates also a series of challenges requiring further research efforts.

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“…[17,18] Concentrating on bone tissue applications and considering polymer based materials (filled polymers and composites), hydroxyapatite, tricalcium phosphate (TCP) or Bioglass are the most popular used fillers. [16,[19][20][21][22][23][24][25][26] Other interesting materials are phosphate glasses, which have readily tuneable properties to improve cellular activity [27][28][29][30][31] or inhibit biofilm formation (antimicrobial glasses). [32][33][34] To date they were rarely used as polymer fillers.…”

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confidence: 99%

Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler

et al. 2010

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Understanding tissue response to materials, to enable modulation and guided tissue regeneration is one of the main challenges in biomaterials science. Nowadays polymers, glasses, and metals dominate as biomaterials. Often native properties of those materials are not sufficient and there is a need to combine them, so as to modify and adjust their properties to the application. The primary aim of this study was to improve cell response to polymer (PLDL) using phosphate glass as filler (titanium doped phosphate glass). As a control β‐tricalcium phosphate (TCP) filler was used. Various concentrations of the filler were used (10–40 vol%). Wetting behavior, ζ‐potentials, mechanical and thermal properties, and human cells response to the materials were evaluated. Results showed that with increase in glass filler loading wettability improved, ζ‐potentials dropped, and increase in stiffness of materials was observed. Importantly cell culture experiments showed more developed and well spread cells on the samples with glass content up to 20 vol%. Cells responded much more positively to the glass filled samples than to TCP filled. However, expression of osteocalcin and osteopontin, proteins that indicate formation of the mineralized structures was positive for all the samples including pure PLDL. It was concluded that due to improved wetting behavior, lower ζ‐potentials, and specific chemistry of the glass filler it was possible to alter cells response, improve bioactivity of the polymer, and vary mechanical properties.

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In vivo Performance of Osteoactivated Cellulose‐Based Scaffolds in Bony Critical‐Size Defects

Cited by 4 publications

References 58 publications

Osteogenic Potential of Graphene in Bone Tissue Engineering Scaffolds

Osteogenic Potential of Graphene in Bone Tissue Engineering Scaffolds

Graphene Oxide/Polymer‐Based Biomaterials

Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler

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