The superotemporal and inferotemporal RNFL bundles converged temporally with increasing myopia, which was associated with an increase in area of abnormal RNFL measurement. The interpretation of the RNFL thickness map in myopic eyes requires careful consideration of the distribution pattern of the RNFL bundles.

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IMPORTANCE Clinical assessment of vision-related disability is hampered by the lack of instruments to assess visual performance in real-world situations. Interactive virtual reality (VR) environments displayed in a binocular stereoscopic VR headset have been designed, presumably simulating day-to-day activities to evaluate vision-related disability.OBJECTIVE To investigate the application of VR to identify vision-related disability in patients with glaucoma. DESIGN, SETTING, AND PARTICIPANTSIn a cross-sectional study, 98 patients with glaucoma and 50 healthy individuals were consecutively recruited from a university eye clinic; all participants were Chinese. The study was conducted between

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This study extends research on the relationship between religious orientation, sexual prejudice, and antipathy toward value-violating behaviors. If intrinsic religion leads individuals to "love the sinner but hate the sin," homosexual sexually promiscuous targets should be treated similarly to heterosexual promiscuous targets. One hundred female introductory psychology students were provided the opportunity to help two students. They had no information about the first student. The second student disclosed through a note that she was gay or said nothing about sexual orientation, and further stated that she was sexually promiscuous or celibate. Participants scoring high in intrinsic religiousness helped the disclosing student less when she revealed she was sexually promiscuous, but did not help a gay discloser less than a straight discloser. High intrinsic scores seemed to be related to antipathy toward the value-violation, but not toward the gay person as an individual.

The ideal exercise time of day (ETOD) remains elusive regarding simultaneous effects on health and performance outcomes, especially in women.Purpose: Given known sex differences in response to exercise training, this study quantified health and performance outcomes in separate cohorts of women and men adhering to different ETOD.Methods: Thirty exercise-trained women (BMI = 24 ± 3 kg/m2; 42 ± 8 years) and twenty-six men (BMI = 25.5 ± 3 kg/m2; 45 ± 8 years) were randomized to multimodal ETOD in the morning (0600–0800 h, AM) or evening (1830–2030 h, PM) for 12 weeks and analyzed as separate cohorts. Baseline (week 0) and post (week 12) muscular strength (1-RM bench/leg press), endurance (sit-ups/push-ups) and power (squat jumps, SJ; bench throws, BT), body composition (iDXA; fat mass, FM; abdominal fat, Abfat), systolic/diastolic blood pressure (BP), respiratory exchange ratio (RER), profile of mood states (POMS), and dietary intake were assessed.Results: Twenty-seven women and twenty men completed the 12-week intervention. No differences at baseline existed between groups (AM vs PM) for both women and men cohorts. In women, significant interactions (p < 0.05) existed for 1RM bench (8 ± 2 vs 12 ± 2, ∆kg), pushups (9 ± 1 vs 13 ± 2, ∆reps), BT (10 ± 6 vs 45 ± 28, ∆watts), SJ (135 ± 6 vs 39 ± 8, ∆watts), fat mass (−1.0 ± 0.2 vs −0.3 ± 0.2, ∆kg), Abfat (−2.6 ± 0.3 vs −0.9 ± 0.5, ∆kg), diastolic (−10 ± 1 vs−5 ± 5, ∆mmHg) and systolic (−12.5 ± 2.7 vs 2.3 ± 3, mmHg) BP, AM vs PM, respectively. In men, significant interactions (p < 0.05) existed for systolic BP (−3.5 ± 2.6 vs −14.9 ± 5.1, ∆mmHg), RER (−0.01 ± 0.01 vs −0.06 ± 0.01, ∆VCO2/VO2), and fatigue (−0.8 ± 2 vs −5.9 ± 2, ∆mm), AM vs PM, respectively. Macronutrient intake was similar among AM and PM groups.Conclusion: Morning exercise (AM) reduced abdominal fat and blood pressure and evening exercise (PM) enhanced muscular performance in the women cohort. In the men cohort, PM increased fat oxidation and reduced systolic BP and fatigue. Thus, ETOD may be important to optimize individual exercise-induced health and performance outcomes in physically active individuals and may be independent of macronutrient intake.

Citation: Wu Z, Lin C, Crowther M, Mak H, Yu M, Leung CK-S. Impact of rates of change of lamina cribrosa and optic nerve head surface depths on visual field progression in glaucoma. Invest Ophthalmol Vis Sci. 2017;58:182558: -183358: . DOI:10.1167 PURPOSE. To investigate the impact of the rates of change of anterior lamina cribrosa surface depth (ALCSD) and optic nerve head surface depth (ONHSD) on visual field (VF) progression in glaucoma. METHODS.One hundred forty-six eyes of 95 glaucoma patients had optical coherence tomography ONH imaging and VF testing at approximately 4-month intervals for greater than or equal to 5 years. Anterior lamina cribrosa surface depth and ONHSD were measured with reference to (1) Bruch's membrane opening (BMO), and (2) choroid-sclera interface (CSI). The rates of change of ALCSD and ONHSD of individual eyes were measured with linear regression analysis. The hazard ratios (HRs) of the rates of change of ALCSD/ONHSD for prediction of VF progression as per Early Manifest Glaucoma Trial criteria were determined by joint longitudinal and survival models.RESULTS. Using the BMO reference, 23.3% and 28.1% of eyes showed a significant positive trend (posterior displacement), whereas 29.5% and 24.0% showed a significant negative trend (anterior displacement) of ALCSD and ONHSD, respectively. Using the CSI reference, the proportions with a significant negative trend decreased to 11.6% and 14.4%, respectively; and the proportions with a significant positive trend increased to 37.7% and 38.4%, respectively. The HRs of VF progression were 1.06 and 1.11 for each micrometer per year increase in the rates of change of ALCSD BMO and ONHSD BMO , respectively; and 1.07 and 1.09 for each micrometer per year increase in the rates of change of ALCSD CSI and ONHSD CSI , respectively. CONCLUSIONS.Identifying fast progressors of posterior ALCS/ONHS displacement is relevant to the management of glaucoma patients as they have a higher risk of VF progression.Keywords: optic nerve head surface depth, anterior lamina cribrosa surface depth, optical coherence tomography O ptic nerve head (ONH) deformation is a defining feature of glaucoma. While confocal scanning laser ophthalmoscopy (CSLO) and optical coherence tomography (OCT) have been widely adopted for measurement of the neuroretinal rim, [1][2][3][4][5][6] parameters like anterior lamina cribrosa surface depth (ALCSD) and ONH surface depth (ONHSD) are rarely examined in clinical practice. Studies reporting long-term, progressive LC and ONH surface deformation in glaucoma patients are sparse. We previously investigated the longitudinal changes of ALCSD and ONHSD in glaucoma patients with reference to Bruch's membrane opening (BMO) using an event analysis. 7 However, event analysis cannot reveal how fast an individual eye is progressing. The rates of change of ALCSD and ONHSD over the course of glaucoma progression have not been reported. The significance of measurement of LC and ONH deformation in the management of glaucoma patients remains unclear.Studie...