Purpose:To determine the impact of a single injection of various anti-inflammatory, antimitotic, and antiangiogenic agents on the cell count of myofibroblasts in an eviscerated socket.Methods:One eye from 15 skeletally mature New Zealand white rabbits was eviscerated, and the rabbits were divided into 5 groups. Each group of 3 rabbits received a 0.1 ml subconjunctival injection of a different agent. Group I received bevacizumab 25 mg/ml, group II received triamcinolone 40 mg/ml, group III received 5-fluorouracil 50 mg/ml, group IV received mitomycin-C 0.4 mg/ml, while group V was the control group and received no injections. The animals were euthanized 19 days after evisceration and conjunctival samples were submitted for histopathological examination. Monoclonal α-smooth muscle actin antibody was applied, and the mean of 5 readings of the number of myofibroblasts was recorded in each slide.Results:The mean count of myofibroblasts was highest for the control group and all groups achieved a statistically significant reduction in myofibroblast count compared with the control group. Sorting the means showed that Group IV (mitomycin-C) achieved the lowest mean value (p = 0.000006) followed by triamcinolone (p = 0.00048), while group I (bevacizumab) achieved the least reduction in myofibroblast count (p = 0.00148).Conclusion:Until newer antimyofibroblast medications and antibodies are commercially available, a single injection of mitomycin-C or triamcinolone during surgery achieves the highest mean reduction of myofibroblast count.
Local chemotherapy for treatment of RB with secondary vitreous seeds is safe and can salvage 30.3% of eyes without EBR. There is a superiority of intravitreal melphalan in ocular salvage however, no statistically significant difference between both groups.
Background
Chronic hyperglycemia in diabetes mellitus causes different morphologic and functional corneal changes.
Aim of the Work
to assess the central corneal thickness in diabetic patients with and without diabetic retinopathy using anterior segment optical coherence tomography.
Patients and Methods
This comparative study was conducted at Ain Shams University hospitals . It included 45 eyes divided into three groups: Group A: 15 eyes of diabetic patients without diabetic retinopathy , Group B: 15 eyes of diabetic patients with diabetic retinopathy and Group C: 15 eyes of non-diabetic individuals.
Results
: The mean CCT in diabetic patients without diabetic retinopathy was 551.13µ ± 37.93 with range 475-622. Diabetics with retinopathy was 558.93µ ± 39.32 with range 508-618 and non diabetics 534.73µ ± 33.67 with range 475-588. There was no significant difference in corneal thickness between the three groups (p = 0.201)
Conclusion
: Diabetic corneas tended to be thicker though this was not statistically significant in our work.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.