Optical Coherence Technology of the Retina

Rashed, Hazem; Izatt, Joseph A.; Toth, Cynthia A.

doi:10.1364/opn.13.4.000048

Cited by 4 publications

(1 citation statement)

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“…Optical coherence tomography ͑OCT͒ can reveal structures within the body to several millimeters in depth with unprecedented resolution on the order of 3 to 15 m, [10][11][12][13] which is an order of magnitude higher than conventional IVUS. Recent ex vivo studies reported in Refs.…”

Section: Introductionmentioning

confidence: 99%

Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

Piao¹,

Sadeghi

Zhang

et al. 2005

J. Biomed. Opt.

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We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.

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Section: Introductionmentioning

confidence: 99%

Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

Piao¹,

Sadeghi

Zhang

et al. 2005

J. Biomed. Opt.

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Development of a high speed and deep scanning optical coherence tomography system

Hasegawa¹,

Matsumura²,

Nakagawa³

et al.

CLEO/Pacific Rim 2003. The 5th Pacific Rim Conference on Lasers and Electro-Optics (IEEE Cat. No.03TH8671)

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An optical coherence tomography system employing an array of retroreflectors mounted on a rotating disk has been developed for ophthalmology. Backscatter signals from the anterior segment and retina of the eye can be detected in a single A-scan.The recent advent of optical coherence tomography (OCT) has allowed ophthalmologists to collect cross-sectional data of pathology involving the posterior vitreous, retina, and subretinal structures of the eye.') In clinical situations such as refractive corneal surgery and intraocular lens implantation, quantitative assessment of the anterior segment using OCT to delineate the corneal thickness and the geometrical distance between the cornea and the fundus oculi would be highly valuable. This requires an optical delay line of several tens of mm, which is not available with the conventional OCT scanners.We report a deep scanning OCT system for clinical use in ophthalmology. Our system employs a retroreflectoiamy mounted on a rotating disk. A schematic diagram of the system is provided in Fig. 1. A super luminescent diode (1=830nm, A l = 2 0 n m ) is used as the low coherence source. The sample arm consists of a pair of X-Y galvanometers for transverse scanning, the imaging lenses, and a dichroic mirror. In the reference arm, the light beam hits the reflective surface of the retroreflector, and is reflected back along the same path to the beamsplitter by the stationary mirror M1. When the retroreflector moves at a constant speed, a patblength difference is generated. Its range is determined by the aperture size of the retroreflector (D), and the radius of the disk (r).To demonstrate the feasibility of the present system, Fig. 2 depicts a 1-D backscatter profile showing the reflection signals from the cornea, the lens, and the retina of the eye. Using a r = 30 mm disk on which four D = 12.7 mm retroreflectors were symmetrically mounted, a 100-Hz longitudinal scanning (A-scan) over a range of 40 mm was achieved by rotating the disk at 1500 rpm.For OCT imaging of the retina, we employed a second disk (r = 30 mm) on which 18 retroreflectors (D = 10 mm) were mounted. The range of A-scan was thus reduced to 4 nun, while the repetition rate was increased to over 400 Hz. As an example, Fig. 3 shows an OCT image of the retina (400 A-lines) acquired in about one second. Detailed results will be presented.

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Blood optical clearing studied by optical coherence tomography

2013

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The main limitation of optical imaging techniques for studying biological tissues is light scattering leading to decreasing of transmittance, which lowers the imaging quality. In this case, an immersion method for optical clearing of biological tissues can provide a possible solution to this problem, because the application of biocompatible clearing agents can reduce light scattering. Optical clearing represents a promising approach to increasing the imaging depth for various techniques, for example, various spectroscopy and fluorescent methods, and optical coherence tomography (OCT). We investigate the improvement of light penetration depth in blood after application of polyethylene glycol, polypropylene glycol, propylene glycol, and hemoglobin solutions using an OCT system. Influence of clearing agents on light transport in tissues and blood was also investigated in the mouse tail vein.

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Optical Coherence Technology of the Retina

Cited by 4 publications

References 0 publications

Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

Development of a high speed and deep scanning optical coherence tomography system

Blood optical clearing studied by optical coherence tomography

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