Gadolinium compounds have been used as a common contrast media in MRI technique; however, they have oxidation-reduction current peaks in blood medium. To propose a solution for this problem, the alternative of contrast media in magnetic resonance imaging (MRI) was studied by electrochemical method using cyclic voltammetric technique. Magnesium compound was chosen such as MgCl 2 which has a good electrochemical properties especially in blood medium. It was found that Mg (II) ions in blood medium acted as an antioxidative reagent. The results of this study focused on the effect of magnesium chloride ions in normal saline, KCl solution and blood medium in presence with ascorbic acid (AA) and folic acid (FA) and understanding the redox current peaks of Mg (II) ions in these conditions. We obtained good results by using MgCl 2 solution as an alternative contrast medium in MRI technique instead of using of gadolinium compounds.
Magnesium chloride compound nanoparticles (MgCl 2 NPs) were chosen as alternative contrast medium in magnetic resonance imaging (MRI). The solution of MgCl 2 NPs was a good electrochemical property especially in the blood medium. It was found that MgCl 2 NPs in blood medium served as an antioxidant reagent because cyclic voltammogram had only one reduction current peak at 0.9 V. Gadolinium compounds were used as a common contrast medium in MRI technique; they had two oxidation current peaks in the blood medium at 0.73 V and 0.23 V. In addition, the gadolinium compounds caused many problems when used as a contrast medium, but they were the only contrast media used for this purpose. It was found that using MgCl 2 NPs solution as an alternative contrast medium in rabbits enhanced MR imaging of kidney organ, as compared with that using gadolinium at the same dose.
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