Use of MgCl2 Nanoparticles as Alternative Contrast Media in Magnatic Resonance Imaging Molecular Imaging and Analyzed by Voltammetric Technique

Abstract

Magnesium chloride compound nanoparticles (MgCl 2 NPs) were chosen as alternative contrast medium in magnetic resonance imaging (MRI). The solution of MgCl 2 NPs was a good electrochemical property especially in the blood medium. It was found that MgCl 2 NPs in blood medium served as an antioxidant reagent because cyclic voltammogram had only one reduction current peak at 0.9 V. Gadolinium compounds were used as a common contrast medium in MRI technique; they had two oxidation current peaks in the blood medium at 0.73 V and 0.23 V. In addition, the gadolinium compounds caused many problems when used as a contrast medium, but they were the only contrast media used for this purpose. It was found that using MgCl 2 NPs solution as an alternative contrast medium in rabbits enhanced MR imaging of kidney organ, as compared with that using gadolinium at the same dose.

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