New Voltammetric Study of MgCl2 as Alternative Contrast Media in MRI Molecular Imaging

Radhi, Muhammed Mizher; Al-Shimmari, Haydar Abdulkadeer Taheer; Al-Mulla, Emad A. Jaffar; Abdullah, Ali Abdulabbas; Wadday, Ahmed Ghanim

doi:10.5101/nbe.v9i2.p152-161

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…MgCl 2 can give high resolution to MR images. It can be used as T1 contrast medium which is a substitute for gadolinium compound, simultaneously, due to the safety and high resolution of MR imaging [9,10]. Manganese (II) complexes have excellent potential as alternative MRI contrast agents to Gd-based probes due to their favorable relaxometric properties and good biochemical characteristics, despite the lower magnetic moment, the shorter Mn-O distance of bound water, and its generally faster exchange rate relaxation values that are quite comparable [11,12].…”

Section: Introductionmentioning

confidence: 99%

Use of MgCl2 Nanoparticles as Alternative Contrast Media in Magnatic Resonance Imaging Molecular Imaging and Analyzed by Voltammetric Technique

Mustafa¹,

Al-Shimmari²,

Radhi³

2020

Nano BioMed ENG

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Magnesium chloride compound nanoparticles (MgCl 2 NPs) were chosen as alternative contrast medium in magnetic resonance imaging (MRI). The solution of MgCl 2 NPs was a good electrochemical property especially in the blood medium. It was found that MgCl 2 NPs in blood medium served as an antioxidant reagent because cyclic voltammogram had only one reduction current peak at 0.9 V. Gadolinium compounds were used as a common contrast medium in MRI technique; they had two oxidation current peaks in the blood medium at 0.73 V and 0.23 V. In addition, the gadolinium compounds caused many problems when used as a contrast medium, but they were the only contrast media used for this purpose. It was found that using MgCl 2 NPs solution as an alternative contrast medium in rabbits enhanced MR imaging of kidney organ, as compared with that using gadolinium at the same dose.

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Section: Introductionmentioning

confidence: 99%

Use of MgCl2 Nanoparticles as Alternative Contrast Media in Magnatic Resonance Imaging Molecular Imaging and Analyzed by Voltammetric Technique

Mustafa¹,

Al-Shimmari²,

Radhi³

2020

Nano BioMed ENG

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“…These subjects should include those with a family history or clinical symptoms, in particular women with a history of multiple abortions. In these cases, there are grounds for suspecting an atypical form of CD [15][16][17][18][19]. Table 8 shows a direct correlation between AtTg IgA and anti-Toxoplasma IgG antibody, and an indirect or negative correlation with anti-Toxoplasma IgM antibody although there was no statistically significant result.…”

Section: Resultsmentioning

confidence: 99%

Role of Anti-Tissue Transglutaminase IgA Antibody in Aborted Women Infected with Toxoplasma Gondii in Association with Latent Coeliac Disease

Chyad¹

2017

Nano Biomedicine and Engineering

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Toxoplasma gondii is an obligate intracellular protozoan parasite that is capable of infecting a variety of intermediate hosts including humans. Infected definitive hosts (cats) shed oocysts in feces that rapidly mature in the soil and become infectious. Vertical transmission of the parasite through the placenta can also occur, leading to congenital toxoplasmosis. Following primary infection, Toxoplasma gondii can remain latent for the life of the host; the risk for reactivation is highest among immunosuppressed individuals. The current study was planned by using 125 pregnant women with single or multiple abortion from different private clinics and hospitals in Babylon province, as well as a control group of 215 pregnant women without history of abortion and 15 apparently healthy women without pregnancy. For all patients and controls, screening tests for anti-Toxoplasma (anti-Toxo) antibody (IgM and IgG) and anti-transglutaminase/Immunoglobulin A (AtTg/IgA) antibody level were done by using ELISA technique in the laboratory of Babylon GIT Center during the period from August 2016 to June 2017. Descriptive and inferential statistical analysis was used to analyze the data. The result revealed that IgG was only indicative of previous exposure to Toxoplasma (recent or past IgG. Women aged 24-35 years were more susceptible to abortion than the other age groups, mostly during the first trimester of pregnancy. There was a relationship between aborted women having toxoplasma infection with AtTg antibody, which might suggest a latent coeliac disease (asymptomatic) that was associated with pregnancy and led to spontaneous abortion. The AtTg IgA had significant negative correlation with age group, time of abortion and abortion number. This result might indicate that AtTg IgA spontaneously increased with time in relation to patient ages as well as specific conditions of aborted women such as time and number of abortion.

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“…One of the diseases that afflict children is autism which is due to the exposure to pollution of lead element in the blood and its effect on the brain [20,21]. One of the main subjects in this field was the presence of lead ions in blood medium and its impact on the brain which causes autism by electrochemical study with cyclic voltammetric technique [22][23][24][25].…”

Section: Resultsmentioning

confidence: 99%

Use of Nano-Sensors of the Interferences between Pb((II) with Each of Mg(II), Zn(II), Mn(II), Ca(II), Co(II) and PO4-3 in Blood Medium: An Electrochemical Study

Abdul-Amir¹,

Radhi²,

Al-Mulla³

2017

Nano BioMed ENG

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Lead is considered a key element in causing autism disease in children due to the pollution of this dangerous element to human. The aim of this research is to obtain a chemical compound with the effect of inhibiting the oxidation of lead ions on the brain that causes the autism disease. Cyclic voltammetric technique was used to study the effect of interferences between lead ions with selected elements such as Mn(II), Mg(II), Zn(II), Ca(II), PO 4 -3 and Co(II) in blood medium. Multi wall carbon nano tube (MWCNT) which was modified with glassy carbon electrode (GCE) was used as a working electrode sensor in cyclic voltammetric method. The results showed that the oxidation and reduction current peaks of Pb(II) ions in the blood medium appeared at -0.2 and -0.8 V respectively. It was found that Co(II) ions had a significant effect on the Pb(II) ions in blood medium as anti-oxidative reagent by reducing the anodic current peak of Pb(II) with five folds and enhancing the cathodic current peak. But other ions such as Mn(II), Mg(II), Zn(II), Ca(II) and PO 4 -3 reduced both redox current peaks of Pb(II) in blood medium. It means that Co(II) ions acted as a good anti-oxidative reagent in blood medium which reduced the effect of lead ions on brain cells by the blood stream. Hence, cobalt compounds could be used as drugs for treatment of the autism disease in children.

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New Voltammetric Study of MgCl2 as Alternative Contrast Media in MRI Molecular Imaging

Cited by 7 publications

References 14 publications

Use of MgCl2 Nanoparticles as Alternative Contrast Media in Magnatic Resonance Imaging Molecular Imaging and Analyzed by Voltammetric Technique

Use of MgCl2 Nanoparticles as Alternative Contrast Media in Magnatic Resonance Imaging Molecular Imaging and Analyzed by Voltammetric Technique

Role of Anti-Tissue Transglutaminase IgA Antibody in Aborted Women Infected with Toxoplasma Gondii in Association with Latent Coeliac Disease

Use of Nano-Sensors of the Interferences between Pb((II) with Each of Mg(II), Zn(II), Mn(II), Ca(II), Co(II) and PO4-3 in Blood Medium: An Electrochemical Study

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