BackgroundThe necrotic skin flap represents a great challenge in plastic and reconstructive surgery. In this study, we evaluated the effect of bioscaffolds, acellular amniotic membranes (AAMs), and bone marrow-derived mesenchymal stem cells (BM-MSCs) on random skin flap (RSF) survival in rats by applying a cell-free extracellular matrix scaffold as a supportive component for the growth and proliferation of BM-MSCs on RSFs. AAM matrix scaffolds were created by incubating AMs in ethylenediaminetetraacetic acid 0.05% at 37°C, and cell scrapers were used.ObjectivesThe aim of the present study was to assess the effect of AAM as a scaffold in TE, and combined with transplanted BM-MSCs, on the survival of RSFs and on the biomechanical parameters of the incision-wound flap margins 7 days after flap elevation.Materials and MethodsBM-MSCs and AAMs were transplanted into subcutaneous tissue in the flap area. On the 7th postoperative day, the surviving flap areas were measured using digital imaging software, and the flap tissue was collected for evaluation. Forty rats were randomly divided into four groups of 10 each: group 1 received an AAM injection; group 2 underwent BM-MSC transplantation; group 3 received both AAM injection + BM-MSC transplantation; and group 4 was the control group, receiving only saline.ResultsThe survival area in the AAM/BM-MSC group was significantly higher than in the control group (18.49 ± 1.58 versus 7.51 ± 2.42, P < 0.05). The biomechanical assessment showed no significant differences between the experimental groups and the control group (P > 0.05), and there was no correlation with flap survival.ConclusionsOur findings showed that the treatment of flaps with BM-MSC and AAM transplantations significantly promoted flap survival compared to a control group. The viability of the flap was improved by combining BM-MSCs with AAM matrix scaffolds.

Background: Patients undergoing any type of nasal surgery may experience degrees of postoperative olfactory dysfunction. We sought to investigate "when" the olfactory function recovers to its preoperative levels.

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Objectives: This research aimed to investigate the psychometric properties of the Persian version of the Multidimensional Body-Self Relations Questionnaire (MBSRQ) among older Iranian people. Methods & Materials: The research method was non-experimental research that its necessary information was collected with the cross-sectional method. The statistical population comprised all older people over 60 years of age in Tehran City, Iran. The statistical sample included 1035 people who have completed the Multidimensional Body-Self Relations Questionnaire (MBSRQ). This questionnaire consists of 69 questions and 9 components. The obtained data were analyzed with confirmatory factorial analysis based on structural equations, Cronbach alpha coefficient, and intra-class correlation coefficient tests. Results: The content, face, and concurrent validity were acceptable (P<0.05). Also, result showed that the MBSRQ has acceptable fit indexes (such as RMSEA=0.042, CFI=0.903, TLI=0.978, PNFI=0.075, and PGFI=0.886). Further, the internal consistency and temporal reliability were acceptable (P<0.05). Conclusion: The Persian version of MBSRQ has acceptable reliability and validity in the Iranian elderly, and researchers, older adults, and elderly specialists can use this questionnaire for its evaluations and research.

Background: There is a lack of epidemiological data on emergency Medical service (EMS) missions for accidents in Iran. The present study aimed at obtaining representative data on the epidemiology of emergency Medical service missions for of accidents in Tehran, during years 2012 to 2013. Methods: Active EMS stations in Tehran were selected through stratified random sampling in different regions of the city during a twelve-month period from March 2012 to March 2013. Data was collected through a questionnaire on demographic information, which extracted from events recorded on dispatch electronic forms in EMS. Data was analyzed by Excel using descriptive statistics. Results: Based on the type of accidents, Road Traffic Accidents (RTA) and downfall in the North, stab wound in the East, burning in the West, and poisoning with CO in the East region of Tehran megacity had the highest rates compared to other areas. The most common of all were Road Traffic Accidents (RTA) (77.9%) stab wound (11.1%), falling down (4.6%), burns (2.1%), and Carbon Monoxide (CO) poisoning (1.5%). Most accidents occurred in males and 20-to 40-year-old age group (45.51%), and the western district had the first rank in Tehran. Conclusions: According to demographic and geographical rate of accidents, It is recommended to develop preparedness programs and response plan according to epidemiological information of accidents. This programs includes EMS staff trainings and community educations.

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