This article includes the synthesis of heterocyclic azo dye of theophylline by coupling diazonium salt of 4-chloroaniline with theophylline which is, namely, 8-(1-(4-chlorophenyl)azo)theophylline (CPAT). The complexes of cobalt and nickel were prepared by reacting their ions with CPAT ligand in ethanol under 1 : 2 ratio metal-ligand. The CPAT ligand and its complexes were characterized by elemental analysis, infrared spectrometry, electronic absorption spectroscopy, molar conductivity, and magnetic moment. The cobalt and nickel complexes show octahedral geometry having general formula [M(CPAT)2Cl2]. This article addresses the properties of CPAT dye such as photochromic properties. The CPAT dye exhibited obvious and desired changes under irradiation with visible light (405 nm), high sensitive for pH changes which refer to its ability to be analysis indicator. CPAT dye exhibited solvatochromic properties presenting red shift with polar solvent. The CPAT and its complexes show interesting antibiological activities towards Staph. aureus and E. coli bacteria and Aspergillus fungi.
In the present work azo dye ligand of 3-aminopyridine (L) and its complexes of NiII and CuII were synthesized, characterized and evaluated for antibacterial and antifungal activities in vitro. The L ligand was synthesized by reacting diazonium ion of 3-aminopyridine with 1-naphthole in presence of sodium acetate. The ligand (L) and its complexes were characterized by elemental analysis (CHN), magnetic susceptibility, molar conductivity, UV-Vis spectra, and infrared technique. The (L) azo dye exhibited high sensing for the pH changes. The color of L dye changed from red in basic medium to yellow color in acidic medium. The data of CHN, UV-Vis and magnetic susceptibility indicate that the complexes [Ni(L)2Cl2] and [Cu(L)2Cl2] are tetrahedral. The complexes of Ni(II) and Cu(II) exhibited potent activity against growth of Staphylococcus aureus and Escherichia Coli as well as against Penicillium Sp. And Aspergillus niger. Under visible irradiation (395 nm), the (L) azo dye of pyridine exhibited a significant change in the spectra under irradiation.
KEY WORDS: Pyridine, Photoisomerization, Pyridylazo, Biological activity, pH sensor
Bull. Chem. Soc. Ethiop. 2020, 34(3), 523-532.
DOI: https://dx.doi.org/10.4314/bcse.v34i3.8
Coordination compounds and organometallics have very special place in chemistry due to their different structural arrangements and application in various fields. They also play vital role in biological system particularly in human and plant life. The blood oxygen carrier haemoglobin is a coordination compound of iron which is essential for human life, also the chlorophyll is a coordination compound of magnesium essential for plant the life and the continuation of the life on this planet. These compounds are not only biologically important but also comprise a group of drug like molecules and medicines. Coordination compounds such as platinum, palladium and ruthenium complexes are anti-cancer drugs. Also, many of the coordination compounds are anti-bacterial. The coordination compounds have been showed effective behaviour against many diseases like Alzheimer’s and malaria. Recently coordination compounds used as antivirus such as coronavirus. In present review, we highlighted the most important coordination complexes that show a significant role in the field of medicine.
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