Synthesis and characterization of new metal complexes containing azo-indole moiety and anti-leukemia human (HL-60) study of its palladium (II) complex

Sahar, Yareeb Jawad; Mohammed, Hasan Shamran; Al-Abady, Zainab N.

doi:10.1016/j.rechem.2023.100847

Cited by 6 publications

(8 citation statements)

References 37 publications

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“…A comprehensive study on metal complexes that have an indole derivative as a bidentate ligand has been conducted by Yareeb J. Sahar et al [ 55 ]. By using (E)-2-(1H-indol-3yl)diazenyl)thiazole (HIDAT) ligand (i.e., L15 ; Figure 14 ) as a starting material, four novel complexes (cobalt, nickel, copper and palladium derivatives) (i.e., 50 – 53 ; Figure 14 ) were obtained and characterized by means of different techniques.…”

Section: Bidentate Ligandsmentioning

confidence: 99%

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Indole-Containing Metal Complexes and Their Medicinal Applications

Kazemi,

Rudbari,

Moini

et al. 2024

Molecules

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Indole is an important element of many natural and synthetic molecules with significant biological activity. Nonetheless, the co-presence of transitional metals in organic scaffold may represent an important factor in the development of effective medicinal agents. This review covers some of the latest and most relevant achievements in the biological and pharmacological activity of important indole-containing metal complexes in the area of drug discovery.

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Section: Bidentate Ligandsmentioning

confidence: 99%

“… 2D interactions between the Pd(II)-HIDAT complex ( 50 ) and tyrosine-protein kinase ABL1 receptor [ 55 ]. …”

Section: Figures and Schemesmentioning

confidence: 99%

Indole-Containing Metal Complexes and Their Medicinal Applications

Kazemi,

Rudbari,

Moini

et al. 2024

Molecules

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“…A comprehensive study on metal complexes that have an indole derivative as a bidentate ligand has been conducted by Yareeb J. Sahar et al [55]. By using (E)-2-(1Hindol-3yl)diazenyl)thiazole (HIDAT) ligand (i.e., L15; Figure 14) as a starting material, four novel complexes (cobalt, nickel, copper and palladium derivatives) (i.e., 50-53; Figure 14) were obtained and characterized by means of different techniques.…”

Section: N N-donormentioning

confidence: 99%

Indole-Based Metal Complexes and Their Medicinal Applications

Kazemi,

Rudbari,

Moini

et al. 2023

Preprint

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The indole nucleus is an important element of many natural and synthetic molecules with significant biological activity. Nonetheless, the co-presence of transitional metals in organic scaffold may represent an important factor in the development of effective medicinal agents. This review covers some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole-based metal complexes in the area of drug discovery.

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“…However, it is important to note that the advantages of azo compounds are dependent on the specific compound and its intended application, and further research is needed to fully understand their potential limitations and drawbacks in drug development. [16,[18][19][20] In the realm of drug studies, computational techniques such as DFT and docking simulations hold significant importance. DFT is a quantum mechanical method that enables the calculation of electronic structure and energy of molecules, which in turn facilitates the prediction of vital drug properties like reactivity, stability, and electronic and vibrational spectra.…”

Section: Introductionmentioning

confidence: 99%

“…Lastly, compared to some other compounds, azo compounds can be relatively inexpensive to synthesize and produce, potentially making them more accessible and affordable for medical use. However, it is important to note that the advantages of azo compounds are dependent on the specific compound and its intended application, and further research is needed to fully understand their potential limitations and drawbacks in drug development [16,18–20] …”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Azo Compounds in Leukemia Treatment: Synthesis and Characterization of New Derivatives with Dimedone and Meldrum's Acid End Groups

Güney,

Dilek,

Sezgin

et al. 2023

ChemistrySelect

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This scholarly investigation presents pioneering drug candidates for combating leukemia, distinguished by reduced side effects and elevated efficacy. The study focuses on azo compounds for their selective targeting against cancerous cells, and customizable properties. Novel azo compounds, DMTPC and DMTPD, were skillfully synthesized via diazotization of 3‐(4‐Methyl‐1H‐imidazol‐1‐yl)‐5‐(trifluoromethyl)aniline with dimedone and meldrum‘s acid. Comprehensive characterization employed advanced analytical techniques like 1H‐NMR, 13C‐NMR, LC‐MS, FT‐IR, and XRD. UV‐Vis and fluorescence spectrophotometers scrutinized absorption and fluorescence properties in diverse solvents. Theoretical DFT computations provided optimized geometries, vibrational frequencies, NMR chemical shifts, absorption wavelengths, HOMOs‐LUMOs, Mulliken charges, and molecular orbital energies. Encouragingly, experimental and theoretical values aligned well. ADME properties and toxicity profiles were evaluated using online web servers. Molecular dynamics simulations explored interactions of DMTPC and DMTPD with the leukemia inhibitory factor protein (PDB ID: 1EMR) compared to Nilotinib. Molecular docking studies indicated DMTPC′s promising potential with a binding energy of −8.8 kcal/mol, approaching Nilotinib's −9.4 kcal/mol. This investigation accentuates the burgeoning research paradigm of exploiting azo compounds in the formidable battle against leukemia, opening new avenues for breakthroughs in this field.

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Synthesis and characterization of new metal complexes containing azo-indole moiety and anti-leukemia human (HL-60) study of its palladium (II) complex

Cited by 6 publications

References 37 publications

Indole-Containing Metal Complexes and Their Medicinal Applications

Indole-Containing Metal Complexes and Their Medicinal Applications

Indole-Based Metal Complexes and Their Medicinal Applications

Exploring the Potential of Azo Compounds in Leukemia Treatment: Synthesis and Characterization of New Derivatives with Dimedone and Meldrum's Acid End Groups

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