Results suggest no significant differences between the Tokyo and Connaught strains in the complete response, recurrence-free survival or adverse event rate.
Increased nucleophosmin expression was a strong predictor of extraurothelial recurrence and cancer-specific survival in patients with N0M0 UTUC undergoing radical nephroureterectomy. Our risk stratification models integrating nucleophosmin expression may provide valuable information on disease recurrence and prognosis.
Purpose: The aim of this study was to investigate the influence of androgen deprivation therapy (ADT) on the progression of non-alcoholic fatty liver disease (NAFLD) in patients with prostate cancer (PCa) by evaluation of hepatic steatosis on computed tomography (CT). Methods: The study included 77 PCa patients who underwent abdominal CT at baseline and after 6 months of ADT. The degree of hepatic steatosis was evaluated according to the attenuation value for liver parenchyma (CT LP ), the attenuation ratio for liver and spleen (LS ratio ), and the difference in attenuation between LS (LS dif ). The associations between these 3 indices and various metabolic syndrome-related factors were analyzed. Results: The number of NAFLD patients increased from 9 (11.6%) at baseline to 16 (20.7%) after ADT. The CT LP , LS ratio , and LS dif values were significantly lower after ADT than before (p < 0.05). There were significant correlations between the percent change in CT LP and the percent change in HbA 1c , between the percent change in LS ratio and the percent change in abdominal circumference, and between the percent change in LS dif and the percent change in BMI. Conclusions: Six months of ADT was associated with significant progression of NAFLD in PCa patients. This progression was strongly correlated with changes in HbA 1c , abdominal circumference, and BMI.
Renal replacement lipomatosis (RRL) is a rare condition that occurs at the end of the spectrum of renal tissue replacement by fat. Xanthogranulomatous pyelonephritis (XGP) is a granulomatous inflammation characterized by destruction of renal parenchyma and replacement by lipid-laden macrophages. We present the case of a 75-year-old man who complained of severe anemia 34 years after right nephrolithotomy. Computed tomography revealed a huge low-density mass with renal parenchyma atrophy on the right side of horseshoe kidney. Right nephrectomy was performed. Pathological diagnosis was RRL with XGP. This is the first report of RRL with XGP in a horseshoe kidney.
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