Massive Renal Replacement Lipomatosis With Foci of Xanthogranulomatous Pyelonephritis in a Horseshoe Kidney

Sawazaki, Harutake; Araki, Daisuke; Ito, Keiichi

doi:10.1016/j.eucr.2016.10.014

Cited by 5 publications

(4 citation statements)

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“…Unilateral heminephrectomy was performed in the 6 cases where the treatment method was specified (5-8, 10, 11). Mortality was reported in only one case (10). Our case is the first case of HSK bilaterally complicated with XGP in the literature that underwent bilateral nephrectomy and was performed kidney transplantation subsequently.…”

Section: Discussionmentioning

confidence: 72%

“…The combination of HSK and XGP is extremely rare and the first case was reported in 1994 by Hammadeh et al (5). There have been only 7 cases reported in the English literature so far (5)(6)(7)(8)(9)(10)(11). The detailed characterization of all cases is presented in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Urinary stone has been reported in the vast majority of cases with HSK manifesting with XGP, including our case. Only one case, who did not have a urinary stone, had a history of nephrolithotomy that was performed 34 years ago (10).…”

Section: Discussionmentioning

confidence: 99%

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Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature

Musayev

Sholan²,

Hasanov

et al. 2021

Acta Med. (Hradec Kralove, Czech Repub.)

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The cases of horseshoe kidney presented by xanthogranulomatous pyelonephritis are very rare. In this study, the case of XGP developing in HSK in a young female patient was presented due to its rare incidence and the previously reported cases were reviewed, as well. The patient, who has end-stage renal disease and was under treatment, admitted to the clinic for preemptive kidney transplantation. Bilateral open en bloc nephrectomy was performed before the kidney transplantation. The histopathological examination of the specimen was reported as XGP. Eight months later, living-donor organ transplantation was performed to the patient with the kidney obtained from her father. XGP can present as a complication of HSK. Moreover, HSK may rarely be manifested by end-stage renal disease in young patients. In such cases, who would undergo kidney transplantation, it is important to examine the HSK in detail and perform bilateral nephrectomy to prevent complications after transplantation.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature

Musayev

Sholan²,

Hasanov

et al. 2021

Acta Med. (Hradec Kralove, Czech Repub.)

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“…For this reason, a number of other trigger mechanisms are considered in XP pathophysiology [15]. One of them is abnormal lipid metabolism [15,16]. …”

Section: Discussionmentioning

confidence: 99%

Early Progression of Xanthogranulomatous Pyelonephritis in Children Might Be Dependent on Vimentin Expression

Ostalska‐Nowicka

Maćkowiak-Lewandowicz

Konwerska

et al. 2017

Am J Case Rep

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Patient: Female, 7Final Diagnosis: Xanthogranulomatosus pyelonephritisSymptoms: LeucocyturiaMedication: —Clinical Procedure: NephrectomySpecialty: NephrologyObjective:Unusual clinical courseBackground:Xanthogranulomatous pyelonephritis (XP) is an extremely rare, severe, atypical form of chronic renal parenchymal inflammation accompanied by hydronephrosis and/or urolithiasis. The pathomechanism of XP is not yet fully understood. Microscopically, XP is indicated by the presence of multinucleated giant cells and lipid-laden macrophages, as well as inflammatory infiltration and intensive renal fibrosis. The lipid accumulation in kidney parenchyma may be secondary to the altered flow of low-density lipoprotein (LDL)-derived cholesterol particles inside the affected cells. Physiologically, the process of LDL-derived cholesterol transport from lysosomes to the sites of its esterification is dependent on vimentin, which is a molecule comprising the cytoskeleton in mesenchymal cells.Case Report:A 7-year old girl was hospitalized because of the finding of unexplained kidney lesions on an abdominal ultrasound examination (an enlarged and deformed collecting system of the right kidney with hyperechogenic, solid, staghorn lesions in the calyces). Three months earlier, the patient had experienced recurrent urinary tract infection. Based on the subsequent laboratory and imaging diagnostics, the final diagnosis of XP was established and the girl was qualified for right-sided nephrectomy Microscopic examination revealed numerous foci of granuloma formations with no evident exponents of dysplastic or neoplastic abnormalities. Significant CD68-positive cell infiltrations and scattered foam cells arranging the numerous foci of granuloma inflammation were noticed. Renal parenchyma, adjacent to granuloma lesions, presented a vimentin expression.Conclusions:Vimentin expression in XP may confirm a focal character of chronic granuloma formation and may suggest the complexity of XP pathogenesis involving not only macrophage and fibroblast activation but also local lipid deregulation and fibrosis.

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Renal Replacement Lipomatosis: From Conception to Birth

Kampantais

Young

Liyanage

2019

Urology

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Massive Renal Replacement Lipomatosis With Foci of Xanthogranulomatous Pyelonephritis in a Horseshoe Kidney

Cited by 5 publications

References 5 publications

Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature

Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature

Early Progression of Xanthogranulomatous Pyelonephritis in Children Might Be Dependent on Vimentin Expression

Renal Replacement Lipomatosis: From Conception to Birth

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