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Breeding experiments with Drosophila melanogaster at high temperatures have demonstrated that at a point 5 C. to 9 C. above the normal optimum of 24 C. no offspring are produced after one generation. This fact was first noted by Northrop (i) for a single stock. Plough and Strauss (2) showed that the exact temperature at which complete sterilization occurred varied with different stocks, but was approximately constant for any

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