The Effect of Temperature on Linkage in the Second Chromosome of Drosophila

Plough, Harold Henry

doi:10.1073/pnas.3.9.553

Cited by 26 publications

(20 citation statements)

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“…Although temperature and stress have long been known to affect recombination rates (Plough 1917;Mavor and Svenson 1923), this is the first study to directly compare chromosome-wide recombination rates for both sexes under different growth conditions. We observed that the size of the genetic map changes in male sperm in response to temperature.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to chromatin, chromosome context and CI, recombination rates are also affected by parental age (Stern 1926) and sex (reviewed in Lenormand and Dutheil 2005), as well as temperature (Plough 1917;Lamb 1969;Rose and Baillie 1979;Saleem et al 2001), radiation (Mavor and Svenson 1923;Muller 1925;Kovalchuk et al 1998), and other stresses (Schewe et al 1971;Barth et al 2000). In most cases, the effects of these factors on recombination have been determined for specific intervals on a chromosome with different chromosome regions responding differently to each stress.…”

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confidence: 99%

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Domain-Specific Regulation of Recombination inCaenorhabditis elegansin Response to Temperature, Age and Sex

2008

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It is generally considered that meiotic recombination rates increase with temperature, decrease with age, and differ between the sexes. We have reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis elegans using physical markers that encompass .96% of chromosome III. The only difference in overall crossover frequency between oocytes and male sperm was observed at 16°. In addition, crossover interference (CI) differs between the germ lines, with oocytes displaying higher CI than male sperm. Unexpectedly, our analyses reveal significant changes in crossover distribution in the hermaphrodite oocyte in response to temperature. This feature appears to be a general feature of C. elegans chromosomes as similar changes in response to temperature are seen for the X chromosome. We also find that the distribution of crossovers changes with age in both hermaphrodites and females. Our observations indicate that it is the oocytes from the youngest mothers-and not the oldest-that showed a different pattern of crossovers. Our data enhance the emerging hypothesis that recombination in C. elegans, as in humans, is regulated in large chromosomal domains.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Domain-Specific Regulation of Recombination inCaenorhabditis elegansin Response to Temperature, Age and Sex

2008

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“…However, rates of sex and recombination can vary between individuals. In particular, stressful conditions have been shown to affect the frequency of sexual reproduction in many organisms, including complete shifts from asexual to sexual reproduction (Kleiven et al, 1992;Mai & Breeden, 2000;Rautiainen et al, 2004;Foster, 2005), and elevated levels of recombination (Plough, 1917;Belyaev & Borodin, 1982;Kupiec, 2000;Abdullah & Borts, 2001; see Hadany &Otto, 2009, andHadany, 2009, for a more comprehensive list of studies). Mathematical and computer simulation models of single-species systems have shown that even in the presence of substantial fitness costs, condition-dependent sex typically evolves much easier than condition-independent sex (Redfield, 1988;Gessler & Xu, 2000;Hadany & Beker, 2003;Hadany & Otto, 2009), and this is true in both haploid and diploid species (Hadany & Otto, 2007).…”

Section: Introductionmentioning

confidence: 99%

Host–parasite coevolution induces selection for condition‐dependent sex

Mostowy

Engelstädter

2012

J of Evolutionary Biology

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Sex and recombination remain one of the biggest riddles of evolutionary biology. One of the most prominent hypotheses, the Red Queen Hypothesis, claims that sex has evolved as a means to efficiently create genotypes that are resistant against coevolving parasites. However, previous models of the Red Queen have assumed that all individuals are equally likely to engage in sexual reproduction, regardless of their infection status, an assumption that may not be true in reality. Here, we consider a population genetic model of a host population coevolving with a parasite population, where the parasites are haploid and the hosts either haploid or diploid. We assume that the probability to engage in sex may be different in infected and uninfected hosts and ascertain the success of different reproductive strategies with a modifier-gene approach. Our model shows that in the large majority of the parameter space, infection-dependent sex is more successful than infectionindependent sex. We identify at least two reasons for this: (i) an immediate short-term advantage of breaking-down gene combinations of unfit individuals and (ii) a selfish spread of the condition-dependent modifiers, in analogy to the 'abandon-ship' effect in single species. In diploids, these effects are often powerful enough to overcome the detrimental effects of segregation. These results raise the intriguing question of why infection-induced sex is not more commonly observed in nature.

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“…An existing method makes use of a Y chromosome transgene that expresses the cell death gene hid under the control of the hsp70 (cited in Starz-Gaiano et al 2001). This method is not suitable for our purposes because heat shock affects recombination frequencies (Plough 1917) and because the effectiveness (percentage of males killed) is variable in our laboratory. As an alternative, we generated a Y chromosome carrying a rpr cell death transgene under the control of a Gal4-inducible promoter, similar to the P { w +mC = UAS-rpr.C} transgene of Aplin and Kaufman (1997).…”

Section: Resultsmentioning

confidence: 99%

Variation in Meiotic Recombination Frequencies Between Allelic Transgenes Inserted at Different Sites in theDrosophila melanogasterGenome

McMahan

Kohl

Sekelsky

2013

G3 Genes|Genomes|Genetics

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Meiotic crossovers are distributed nonrandomly across the genome. Classic studies in Drosophila suggest that the position of a gene along a chromosome arm can affect the outcome of the recombination process, with proximity to the centromere being associated with lower crossing over. To examine this phenomenon molecularly, we developed an assay that measures meiotic crossovers and noncrossover gene conversions between allelic transgenes inserted into different genomic positions. To facilitate collecting a large number of virgin females, we developed a useful genetic system that kills males and undesired classes of females. We found that the recombination frequency at a site in the middle of the X chromosome, where crossovers are normally frequent, was similar to the frequency at the centromere-proximal end of the euchromatin, where crossovers are normally infrequent. In contrast, we recovered no recombinants—crossovers or noncrossovers—at a site on chromosome 4 and at a site toward the distal end of the X chromosome. These results suggest that local sequence or chromatin features have a stronger impact on recombination rates in this transgene assay than position along the chromosome arm.

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The Effect of Temperature on Linkage in the Second Chromosome of Drosophila

Cited by 26 publications

References 1 publication

Domain-Specific Regulation of Recombination inCaenorhabditis elegansin Response to Temperature, Age and Sex

Domain-Specific Regulation of Recombination inCaenorhabditis elegansin Response to Temperature, Age and Sex

Host–parasite coevolution induces selection for condition‐dependent sex

Variation in Meiotic Recombination Frequencies Between Allelic Transgenes Inserted at Different Sites in theDrosophila melanogasterGenome

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