Forty-four compounds currently undergoing carcinogenesis bioassay by the National Toxicology Program were submitted to the TOPKAT program for prediction of their potential carcinogenicity. Sixteen compounds could not be handled by TOPKAT. Of the 28 for which predictions were made, 26 (93%) had a confidence level in the estimate of at least moderate. Seventeen were predicted to be carcinogens and 11 non-carcinogens. These results will be compared with the assay results as the assays are completed.
A peculiar sweetish odor was noted in the exhaled breath of cats treated with dimethylsulfoxide. By means of gas chromatographic and mass spectrographic techniques, the responsible compound was identified as dimethylsilfid.
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