Solubilities of Ethylene, Cyclopropane, Halothane and Diethyl Ether in Human and Dog Blood at Low Concentrations

Blood solubility of isoflurane measured by amultiple gas phase equilibration technique

“…Generalizing equation (6) k~Xo (7) G~---(he + 1)" or (8) log Gn = -[log (he + 1)]n + log h~Xo Equation (8) Thus, plotting log G~ as a function of n should yield a linear relationship (as in Figure 1), the negative slope of which is log (h.e + 1) and the intercept log hoXo.…”

The Variability of Partition Coefficients for Halothane in the Rabbit

“…The complex effects of proteins on the solubility of halothane have been discussed recently by Laasberg and Hedley-Whyte (1970). Han and Helrich (1966) and Cowles, Borgstedt and Gillies (1971) give equations for the regression of halothane solubility in blood on haemoglobin concentration which are similar to each other but are somewhat in conflict with the data of Laasberg and Hedley-Whyte. If these equations are valid they could be useful in predicting blood solubility coefficients for individuals, Downloaded from https://academic.oup.com/bja/article/44/7/656/331144 by guest on 14 September 2020 3.8 0.7 -0.7 --1.0 -0.7 0.5 0.9 0.6 2.7 0.7 0.9 0.6 0.5 0.9 0.8 0.8 0.9 0.6 0.7 0.9 0.5 0.6 0.9 0.05 •Present study corrected to 37 °C.…”

Solubility and Distribution of Halothane in Human Blood *

“…Experimental observations on these relationships are, however, in conflict. Several investigators (Hans and Helrich, 1966;Lowe and Hagler, 1969;Cowles, Borgstedt and Gillies, 1971) have reported a decrease in solubility with an increase in haematocrit, while other studies have shown that the solubility of halothane is independent of the haematocrit (Saraiva et al, 1977), that halothane is less soluble in blood of low haematocrit (Ellis and Stoelting, 1975) or more soluble in bloodofhighhaematocrit (Steward, AllotandMapleson, 1975). Ithas also been reported that lipid concentration either increased (Larson, Eger and Severinghaus, 1962;Wagner, Naumann and Laravuso, 1974;Saraiva et al, 1977) or was not correlated with (Munson et al, 1978) the solubility of halothane, and that the solubility was dependent upon the albumin : globulin ratio (Laasberg and Hedley-Whyte, 1970).…”

“…0007-0912/80/090851-12 $01.00 Eyring, 1974;Hansch ct al., 1975;Richards, 1976;Haydon et al, 1977), one might expect that a significant proportion of the anaesthetic agent would be transported by the red cell membrane. However, there has been no conclusive evidence presented for or against this theory and it has been reported variously that the solubility of anaesthetics in blood has either a positive or a negative dependence on, or is independent of, haematocrit (Muehlbacher and Debon, 1966;Laasberg and Hedley-Whyte, 1970;Cowles, Borgstedt and Gillies, 1971;Eger, 1974;Ellis and Stoelting, 1975;Steward, Allot and Mapleson, 1975;Saraiva et al, 1977). These contradictory results are probably a result of the lack of both a systematic approach and precise knowledge of the composition of the systems examined.…”