The present data highlights that onychomycosis may be a growing medical concern among ageing patients.

Context:Role of Ozurdex in macular edema due to various posterior segment pathologies.AIM:The aim of this study is to report outcome of Ozurdex implant in macular edema (ME) secondary to various posterior segment pathologies.SETTINGS AND DESIGN:This was a single-center, retrospective, interventional study.SUBJECTS AND METHODS:Patients of ME were treated with one or more Ozurdex implants (0.7 mg). Data collection included demographic details, best-corrected visual acuity (BCVA), central foveal thickness (CFT), duration of efficacy, and record of adverse events (if any) within 24 weeks.STATISTICAL ANALYSIS USED:Paired sample t-test, Stata data analysis, and statistical software, version 12.1, StataCorp, College Station, TX, USA, were used in the study.RESULTS:One hundred and sixteen eyes of 104 patients were studied which had a diagnosis of diabetic ME (n = 46), retinal vein occlusion (n = 40), and uveitis (n = 30). The average age of patients (mean ± standard deviation) was 50.2 ± 21.9 years. Baseline mean ± SD (standard deviation) logMAR BCVA, CFT, and intraocular pressure (IOP) were 0.636 ± 0.4, 527.8 ± 210.1 μm, and 15.3 ± 3.8 mmHg, respectively. The reinjection interval was around 12–18 weeks. Ozurdex proved its efficacy in improving mean logMAR visual acuity and reduction of CFT from baseline till 12 weeks' follow-up period (0.414 ± 0.5 and 301.5 ± 278.5, respectively; P < 0.05), and after 12 weeks' follow-up, it started worsening (0.530 ± 0.9 and 444.8 ± 375.2, respectively; P > 0.05). The most common reported adverse event was significant rise of IOP (>5 mmHg), with a total of 12 cases followed by cataract 9 cases.CONCLUSION:Ozurdex implant leads to a significant improvement in BCVA and CFT values till 12 weeks, followed by a gradual decline for all the pathologies studied together. No new safety concerns were observed with the Ozurdex implant. The duration of efficacy was found to be <24 weeks.

Clinical baseline characteristics and the early treatment response were identified as possible predictors for long-term outcome and the need of adjunctive intravitreal therapy in MO secondary to BRVO/CRVO treated by DEX implant.

Asthma is a significant health problem worldwide and Allergic Bronchopulmonary aspergillosis (ABPA) complicates the course of 1-2% of patients of asthma. Aspergillus skin hypersensitivity (AH) is the first step for diagnosis of ABPA. This study was conducted to know the correlation of AH with severity and duration of asthma. Patients, age >15 years, of asthma attending this hospital from January 2015 to December 2015 were included. Asthma was diagnosed clinically and confirmed with spirometry. Of 282 patients 206 patients were AH positive. The AST-positivity in patients having severe asthma (96.8%) was higher than that in patients having mild (36.8%) and moderate asthma (80.4%). The median (IQR) duration of asthma of AH positive patients was 5.0 yrs. This study emphasized the need of ABPA screening by intradermal skin test especially in patients having severe asthma and/or those having asthma for longer duration in order for early diagnosis of ABPA.

Materials and Methods:-25 eyes receiving Ozurdex implant (0.7mg dexamethasone) for treatment of naïve non-infectious intermediate or posterior uveitis with cystoid macular edema (CME) having a minimum 6 month follow up. Best corrected visual acuity (BCVA) and central foveal thickness (CFT) was measured at baseline, 1, 3 & 6 months. Results:-Mean baseline logMAR BCVA improved significantly from 0.477 to 0.181 (p<0.05) at 3 months and to 0.193 (p<0.05) at 6 months. The mean CFT reduced from its baseline value of 481.3µ to 250.41µ (p<0.05) at 3 months and to 274.8µ(p<0.05) at 6 months. Conclusion:-Significant improvement in BCVA and CFT from baseline to 3 and 6 months has proven Ozurdex implant to be a promising treatment option in cases of treatment naïve non-infectious posterior uveitis.

Intraocular foreign bodies (IOFBs) are an important cause of visual loss. The current case describesa case of retained intraocular foreign body with secondary retinal detachment in a phakic eye in a38-year-old man. The foreign body was safely removed through the sclerotomy port withouttouching the crystalline lens. The current case report wanted to show the anatomic and visualoutcomes of vitreoretinal surgery in such cases.

Dengue is an acute viral illness caused by RNA virus of the family Flaviviridae and spread by Aedes mosquitoes. Presenting features may range from asymptomatic fever to dreaded complications such as hemorrhagic fever and shock. A decreased number of white blood cells (leukopenia) accompanied by a decreased number of platelet count (thrombocytopenia) and metabolic acidosis are the initial changes on laboratory examinations. Microbiological laboratory testing conrms the diagnosis of Dengue Fever. Virus segregation in cell cultures, nucleic acid demonstration by polymerase chain reaction (PCR), and serological detection of viral antigens (such as NS1) or particular antibodies are the preferred microbiological assays. This study focuses on the importance of platelet counts and other platelet parameters in dengue infection. Also platelet counts are compared with clinical, radiological and other serological markers.

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