The prevalence of unsuspected onychomycosis and its causative organisms in a multicentre Canadian sample of 30 000 patients visiting physicians' offices

Gupta, Aditya K.; Gupta, Gita; Jain, Hardik; Lynde, Charles; Foley, Kelly A.; Daigle, Deanne; Cooper, Elizabeth A.; Summerbell, Richard C.

doi:10.1111/jdv.13677

Cited by 68 publications

(76 citation statements)

References 25 publications

(73 reference statements)

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“…The high prevalence of fungal infections in North America is largely due to the immigration of dermatophytes from other areas of the world such as West Africa and Southeast Asia. The global prevalence of onychomycosis is estimated to be around 5.5%, attributing to 50.0% of all nail disease cases . The risk of onychomycosis increases with age due to poor peripheral circulation, diabetes, repeated nail trauma, longer exposure to pathogenic fungi, suboptimal immune function, inactivity, and/or the inability to maintain good foot care .…”

Section: Epidemiologymentioning

confidence: 99%

“…The global prevalence of onychomycosis is estimated to be around 5.5%, attributing to 50.0% of all nail disease cases . The risk of onychomycosis increases with age due to poor peripheral circulation, diabetes, repeated nail trauma, longer exposure to pathogenic fungi, suboptimal immune function, inactivity, and/or the inability to maintain good foot care . Toenail onychomycosis is more common in males with Candida fingernail onychomycosis more common in women .…”

Section: Epidemiologymentioning

confidence: 99%

“…Onychomycosis is found more frequently in the elderly . Age‐related nail changes can affect the success of antifungal treatment .…”

Section: Special Populationsmentioning

confidence: 99%

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Global perspectives for the management of onychomycosis

et al. 2018

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Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophyte molds, and yeasts. This difficult‐to‐treat chronic infection has a tendency to relapse despite treatment. This paper aims to offer a global perspective on onychomycosis management from expert physicians from around the world. Overall, the majority of experts surveyed used systemic, topical, and combination treatments approved in their countries and monitored patients based on the product insert or government recommendations. Although the basics of treating onychomycosis were similar between countries, slight differences in onychomycosis management between countries were found. These differences were mainly due to different approaches to adjunctive therapy, rating the severity of disease and use of prophylaxis treatment. A global perspective on the treatment of onychomycosis provides a framework of success for the committed clinician with appreciation of how onychomycosis is managed worldwide.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

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Global perspectives for the management of onychomycosis

et al. 2018

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“…Clinical trials usually enroll dermatophyte-confirmed onychomycosis, yet recent epidemiological studies have reported a prevalence of nondermatophyte/mixed infections ranging from 28 to 48% [13,14]. Although the present study included few patients with these infections ( n = 18), mycological cure was observed in 13 patients.…”

Section: Discussionmentioning

confidence: 60%

A Retrospective Study Comparing K101 Nail Solution as a Monotherapy and in Combination with Oral Terbinafine or Itraconazole for the Treatment of Toenail Onychomycosis

Shemer

Gupta

Babaev

et al. 2017

Skin Appendage Disord

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Background: Onychomycosis is a difficult-to-treat fungal infection of the nails. The efficacy of monotherapy is not ideal, and combination therapies provide an alternative that may increase treatment efficacy. Method: A retrospective analysis of data from 91 patients was undertaken. Treatment for toenail onychomycosis occurred between 2014 and 2016 and consisted of combination therapy with oral terbinafine (250 mg/day for 12 weeks) or itraconazole (3 pulses, 400 mg/day for 7 days) + K101 nail solution daily, or K101 nail solution monotherapy. Efficacy outcomes at 12 and 15 months were analyzed. Results: At 12 months, the clinical cure rate for combination of terbinafine + K101 solution was significantly higher than that for K101 monotherapy (p = 0.008). Patients receiving this combination also showed significant improvement in percent of affected nail at 3 months (p = 0.029), while patients receiving itraconazole + K101 solution demonstrated improvement in percent of affected nail at 6 months (p = 0.037). At 15 months, there was no significant difference between treatments for complete, clinical, and mycological cure. Conclusion: Combination therapy with oral terbinafine or itraconazole and K101 nail solution results in clearance of infected nail earlier than that with topical K101 alone. These combinations may encourage compliance and be effective for patients with moderate onychomycosis.

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“…Onychomycosis is a fungal infection of nails [1]. It accounts for half of all nail disorders and its prevalence has been increasing.…”

Section: Introductionmentioning

confidence: 99%

Clinico-Mycological Study of Fungal Biofilms in Recalcitrant Onychomycosis

Mr¹,

Mh²,

Hm³

et al. 2017

Mycobact Dis

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Objective: Studying the incidence of different predisposing factors of onychomycosis and the ability of fungal isolates to form biofilms. Background:Onychomycosis chronicity is referred to difficulties in eliminating the causative pathogens. Biofilms have become focus of era and considered to be one of the globally important causes of chronic recalcitrant infections. Fungi implicated in onychomycosis have the ability to form biofilms ''surface-attached multi-cellular communities''. Biofilm associated fungi acquire higher adaptive ability to overcome stressful conditions, higher antifungal resistance and evasion of host defensive systems. Moreover, they express community-based differential genes and more virulence activities.

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The prevalence of unsuspected onychomycosis and its causative organisms in a multicentre Canadian sample of 30 000 patients visiting physicians' offices

Abstract: The present data highlights that onychomycosis may be a growing medical concern among ageing patients.

Cited by 68 publications

References 25 publications

Global perspectives for the management of onychomycosis

Global perspectives for the management of onychomycosis

A Retrospective Study Comparing K101 Nail Solution as a Monotherapy and in Combination with Oral Terbinafine or Itraconazole for the Treatment of Toenail Onychomycosis

Clinico-Mycological Study of Fungal Biofilms in Recalcitrant Onychomycosis

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