In this research, Magnesium oxide nanoparticles (MgONPs) was prepared from MgCl2 solution using aqueous extract of M. oleifera bark as green agent. Preparation procedure involved mixing of MgCl2.6H2O solution and the aqueous extract of M. oleifera bark, followed by drop wise addition of NaOH solution. The formation of MgO nanoparticles in this synthesis was confirmed using UV-Vis absorption. The spherical crystal structure of MgO nanoparticle confirmed XRD analysis. The average particle size of the synthesized MgO nanoparticles measured between 60 - 100 nm using SEM and TEM images and PSA results. MgONPs synthesized showed good antioxidant activity and antibacterial activity against S. aureus, E. faecalis, E. coli, and S. dysenteriae bacteria.
In this research, nano-size MgO (NS-MgO) was prepared from MgCl2 solution using aqueous extract of Moringa oleifera leaves (AEMOL) as green agent. Preparation procedure involved mixing of MgCl2.6H2O solution and the AEMOL, followed by dropwise addition of NaOH solution. The formation of NS-MgO in this synthesis was confirmed using UV-Vis absorption. The spherical crystal structure of NS-MgO was confirmed by XRD analysis. The average particle size of the synthesised NS-MgO was found between 40–70 nm using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images and particle size analyser (PSA) results. Based on the maximum inhibition concentration (MIC) it was found that the NS-MgO has good antibacterial activity against S. aureus, E. faecalis, E. coli, and S. dysenteriae bacteria (MIC values: 250–500 μg ml−1), and much stronger antifungal activity against A. flavus, A. niger, and C. albican (MIC values: 62.5–125 μg ml−1). These findings suggest prospective potential of NS-MgO synthesised as therapeutic candidate for the treatment of candidiasis.
Kurkumin merupakan salah satu senyawa metabolit sekunder golongan fenolik yang dikenal memiliki aktivitas biologis yang penting, seperti antibakteri, antikanker, antioksidan, antidiabetes dan antiinflamasi. Dalam penelitian ini, sintesis senyawa analog kurkumin berbahan dasar veratraldehida telah dilakukan.Tahap sintesis melibatkan kondensasi Claisen-Schimdt dari veratraldehida dan siklopentanon menggunakan katalis basa (KOH) dalam pelarut etanol serta dilakukan dengan metode ultrasound selama 15 menit, menghasilkan senyawa analog kurkumin ((2E,5E)-2,5- bis(3,4-dimetoksibenzilidin) siklopentanon). Hasil senyawa tersebut dianalisis dengan mengunakan DI-MS, dan spektra FTIR. Hasil penelitian menunjukkan bahwa 15,4 mmol veratraldehida yang disintesis dengan 7 mmol siklopentanon menggunakan katalis basa (KOH) 5% dalam pelarut etanol menghasilkan rendemen sebesar 85,71% dan mempunyai berat molekul 380 g/mol. Hasil sintesis senyawa analog kurkumin dari metode ultrasound berupa serbuk kuning dengan titik leleh 194 °C.
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