Mg(OH) 2 nanocrystallines with rod-, tube-, needle-, or lamella-like morphologies have been synthesized by a hydrothermal reaction using different magnesium precursors and solvents as the reactants. The products appeared to have narrow size distributions with a monodisperse nature. Subsequent thermal decomposition at 450 °C gave nanosized MgO, which preserved well the morphological features of the Mg(OH) 2 samples. The specific surface areas of the MgO samples were determined by the BET technique, which gave a feature of high surface area generally larger than 100 m 2 /g. The channels formed in the thermal dehydroxylation process may account for this feature of the MgO nanocrystallines. CM000607E

Recent studies have boosted our understanding of long noncoding RNAs (lncRNAs) in numerous biological processes, but few have examined their roles in somatic cell reprogramming. Through expression profiling and functional screening, we have identified that the large intergenic noncoding RNA p21 (lincRNA-p21) impairs reprogramming. Notably, lincRNA-p21 is induced by p53 but does not promote apoptosis or cell senescence in reprogramming. Instead, lincRNA-p21 associates with the H3K9 methyltransferase SETDB1 and the maintenance DNA methyltransferase DNMT1, which is facilitated by the RNA-binding protein HNRNPK. Consequently, lincRNA-p21 prevents reprogramming by sustaining H3K9me3 and/or CpG methylation at pluripotency gene promoters. Our results provide insight into the role of lncRNAs in reprogramming and establish a novel link between p53 and heterochromatin regulation.

A novel Ni3N/graphene nanocomposite has been synthesized as pseudo supercapacitor electrode material with high capacitance and energy density, due to its unique two-step oxidation/reduction reaction mechanism.

3–8 nm sized high quality graphene quantum dots with zigzag edges and multi-heteroatom doping were synthesized through a green process of electrochemically cutting pristine few-layer graphene flakes.

Compared with indirect assessments, such as mouth opening and other parameters, mandibular condylar mobility, as assessed directly using sonography, was correlated with difficult laryngoscopy and demonstrated an independent and notably predictive property.

Magnesium-based materials are preferred in temporary orthopedic implants because of their biodegradability, mechanical properties, and intrinsic antibacterial properties. However, the fundamental mechanism of bacteria killing and roles of various factors are not clearly understood. In this study, we performed a systematic study of the antibacterial properties of two common Mg-based materials using a biofilm forming bacterium. Complete annihilation of the initial 3 × 10(4) bacteria is achieved with both materials in 0.1 mL LB medium in 24 h, whereas in the control, they proliferate to 10(10). The bacteria are killed more effectively in the solution than on the surface, and the bacteria killing efficiency depends more on the concentrations of the magnesium ions and hydroxyl ions than the corrosion rate. The killing process is reproduced using formula solutions, and killing is revealed to stem from the synergetic effects of alkalinity and magnesium ions instead of either one of them or Mg(OH)2 precipitate. Reactive oxygen species (ROS) are detected from the bacteria during the killing process but are not likely produced by the redox reaction directly, because they are detected at least 3 h after the reaction has commenced. The average cell size increases during the killing process, suggesting that the bacteria have difficulty with normal division which also contributes to the reduced bacteria population.

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