With recent advances in mass spectrometry, there is an increased interest in data-independent acquisition (DIA) techniques for metabolomics. With DIA technique, all metabolite ions are sequentially selected and isolated using a wide window to generate multiplexed MS/MS spectra. Therefore, DIA strategy enables a continuous and unbiased acquisition of all metabolites and increases the data dimensionality, but presents a challenge to data analysis due to the loss of the direct link between precursor ion and fragment ions. However, very few DIA data processing methods are developed for metabolomics application. Here, we developed a new DIA data analysis approach, namely, MetDIA, for targeted extraction of metabolites from multiplexed MS/MS spectra generated using DIA technique. MetDIA approach considers each metabolite in the spectral library as an analysis target. Ion chromatograms for each metabolite (both precursor ion and fragment ions) and MS(2) spectra are readily detected, extracted, and scored for metabolite identification, referred as metabolite-centric identification. A minimum metabolite-centric identification score responsible for 1% false positive rate of identification is determined as 0.8 using fully (13)C labeled biological extracts. Finally, the comparisons of our MetDIA method with data-dependent acquisition (DDA) method demonstrated that MetDIA could significantly detect more metabolites in biological samples, and is more accurate and sensitive for metabolite identifications. The MetDIA program and the metabolite spectral library is freely available on the Internet.

A new lower tungsten divertor has been developed and installed in the EAST superconducting tokamak to replace the previous graphite divertor with power handling capability increasing from <2 MW m−2 to ∼10 MW m−2, aiming at achieving long-pulse H-mode operations in a full metal wall environment with the steady-state divertor heat flux of ∼10 MW m−2. A new divertor concept, ‘corner slot’ (CS) divertor, has been employed. By using the ‘corner effect’, a strongly dissipative divertor with the local buildup of high neutral pressure near the corner can be achieved, so that stable detachment can be maintained across the entire outer target plate with a relatively lower impurity seeding rate, at a separatrix density compatible with advanced steady-state core scenarios. These are essential for achieving efficient current drive with low-hybrid waves, a low core impurity concentration and thus a low loop voltage for fully non-inductive long-pulse operations. Compared with the highly closed small-angle-slot divertor in DIII-D, the new divertor in EAST exhibits the following merits: (1) a much simpler geometry with integral cassette body structure, combining vertical and horizontal target plates, which are more suitable for actively water-cooled W/Cu plasma facing components, facilitating installation precision control for minimizing surface misalignment, achieving high engineering reliability and lowering the capital cost as well; (2) it has much greater flexibility in magnetic configurations, allowing for the position of the outer strike point on either vertical or horizontal target plates to accommodate a relatively wide triangularity range, δ l = 0.4–0.6, thus enabling to explore various advanced scenarios. A water-cooled copper in-vessel coil has been installed under the dome. Five supersonic molecular beam injection systems have been mounted in the divertor to achieve faster and more precise feedback control of the gas injection rate. Furthermore, this new divertor allows for double null divertor operation and slowly sweeping the outer strike point across the horizontal and vertical target plates to spread the heat flux for long-pulse operations. Preliminary experimental results demonstrate the ‘corner effect’ and are in good agreement with simulations using SOLPS-ITER code including drifts. The EAST new divertor provides a test-bed for the closed divertor concept to achieve steady-state detachment operation at high power. Next step, a more closed divertor, ‘sharp-cornered slot’ divertor, building upon the current CS divertor concept, has been proposed as a candidate for the EAST upper divertor upgrade.

Si nanowires (NWs) were doped with large amounts of Li+ ions by an electrochemical insertion method at room temperature. Si NWs with different doping levels were obtained by controlling the discharging/charging of Li/Si NWs cell. The microstructures of Si NWs with different doses of Li+ ions were investigated by high-resolution electron microscopy. The crystalline structure of the Si NWs was destroyed gradually with the increasing of Li+ ion dose. When the Li+ ions were extracted from the amorphous Li-doped Si NWs by the same electrochemical method, local ordering of atoms occurred and recrystallization was observed. The photoluminescence peak and intensity of Li+-doped Si NWs are closely related to the doping dose.

Polymerized carbon nitride nanobells (CNNBs) have been intercalated by a large amount of Li ions using an electrochemical method. Li nanocrystals are observed on the inside surface of CNNB walls, which is direct evidence that a Li nanocrystal can exist at the micropore structure at a heavy intercalating level. Graphene layers are expanded and become partly disordered by Li intercalation, while after deintercalation, they are reordered to a certain degree, and Li nanocrystals disappear. The samples show a reversible Li storage capacity of 480 mAhg−1, much higher than 330 mAhg−1 of commercial carbon materials used for Li ion batteries.

Since the magnetic field is responsible for most manifestations of solar activity, one of the most challenging problems in solar physics is the diagnostics of solar magnetic fields, particularly in the outer atmosphere. To this end, it is important to develop rigorous diagnostic tools to interpret polarimetric observations in suitable spectral lines. This paper is devoted to analyzing the diagnostic content of linear polarization imaging observations in coronal forbidden lines. Although this technique is restricted to off-limb observations, it represents a significant tool to diagnose the magnetic field structure in the solar corona, where the magnetic field is intrinsically weak and still poorly known. We adopt the quantum theory of polarized line formation developed in the framework of the density matrix formalism, and synthesize images of the emergent linear polarization signal in coronal forbidden lines using potential-field source-surface magnetic field models. The influence of electronic collisions, active regions, and Thomson scattering on the linear polarization of coronal forbidden lines is also examined. It is found that active regions and Thomson scattering are capable of conspicuously influencing the orientation of the linear polarization. These effects have to be carefully taken into account to increase the accuracy of the field diagnostics. We also found that linear polarization observation in suitable lines can give valuable information on the long-term evolution of the magnetic field in the solar corona.

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