Aim: It was directed to evaluate rosmarinic acid (RA) effect as a chemopreventive modality on experimentally induced hamster buccal pouch (HBP) carcinogenesis. Material and methods: Forty Syrian male hamsters five weeks old, weighing 120-80g, were divided into four groups of ten hamsters in each as follows, GI: Only topical application of liquid paraffin (3 times a week for 14 weeks), GII: Topical application of 12 ,7 dimethyl benz[a]anthracene (DMBA) alone (%0.5 in liquid paraffin, 3 times a week for 14 weeks), GIII: Topical application of DMBA (%0.5 in liquid paraffin, 3 times a week for 14 weeks) associated by oral administration of RA (100mg/kg b.w in 1ml distilled water by oral gavage, 3 times a week for 14 weeks on opposite days of DMBA application), GIV : Oral administration of RA alone (100mg/kg b.w in 1ml distilled water by oral gavage, 3 times a week for 14 weeks). Results: Gross observation and histopathological findings revealed a-GI: normal stratified squamous epithelium b-GII: well and moderately differentiated SCC c-: GIII: revealed considerably reversed tumor incidence d: GIV: normal similar to GI. Immunohistochemical results revealed, oral administration of RA to DMBA treated hamsters restored the normal expression of bcl2-and Bax indicating that RA may have chemopreventive mechanism and/or pro-apoptotic effects. Conclusion: RA may act through different mechanisms, such as applying anti-inflammatory, antioxidant results as well as impede cell proliferation, migration, and selectively convince cancer cells apoptosis.
Objective:The objective of the present study was to compare the effect of mixing simvastatin with Nanobone graft on the healing process of extraction sockets regarding to the histological parameter. Materials and Methods: In a prospective randomized clinical study, ten patients (study group, Group II) treated by simvastatin mixed with Nanobone after tooth extraction. The other ten patients (Control group, Group I) received Nanobone only. Three months after tooth extraction and socket preservation, histological biopsies were taken at the time of implant placement. The biopsies were evaluated in the terms of the histological parameter for the identification of vascularization and bone metabolism factors. Results: The use of simvastatin combination results in slightly higher values of mineralized area of newly formed bone andnumerous well differentiated capillary vascularization. Conclusion: Simvastatin and Nanobone combination showed improvement in socket preservation.
Aim: The aim of this study was to evaluate the effect of pilocarpine on the histological changes, induced by exposure to radiation therapy, in the rat's lingual salivary glands. Subjects and methods: This study was carried on 30 adult male Sprague-Dawley rats weighing 150-250 g. That the rats were divided into 3 groups (10 rats per each). Group I: Control group received neither radiation nor drug. Group II: exposed to a single whole body γ-irradiation at dose of 6 Gray (Gy). Group (3): the rats were injected intraperitoneally by a single dose of pilocarpine hydrochloride (0.2 mg/kg) 90 minute before the exposure of the previous dose of radiation. Results: One week after x-ray radiation the glands demonstrated marked destructive changes. These changes comprise in the form of loss of acinar architecture, and acinar degeneration and atrophy. Pilocarpine administration prior to radiation has decreased, but not completely prevents, the harmful effects of radiation. The radioprotective effect of pilocarpine treatment was manifested by the decreased atrophic changes and the absence of degenerated acinar cells. Conclusion: Administration of pilocarpine can protect, to some extent, the lingual salivary glands against radiation histological damage.
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