Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As2O3) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARalpha (a fusion protein containing sequences from the PML zinc finger protein and retinoic acid receptor alpha). PML and PML-RARalpha degradation is triggered by their SUMOylation, but the mechanism by which As2O3 induces this posttranslational modification is unclear. Here we show that arsenic binds directly to cysteine residues in zinc fingers located within the RBCC domain of PML-RARalpha and PML. Arsenic binding induces PML oligomerization, which increases its interaction with the small ubiquitin-like protein modifier (SUMO)-conjugating enzyme UBC9, resulting in enhanced SUMOylation and degradation. The identification of PML as a direct target of As2O3 provides new insights into the drug's mechanism of action and its specificity for APL.
local scanning. First, an objectness-based segmentation method is introduced to extract semantic objects from the current scene surface via a multi-class graph cuts minimization. Then, an object of interest (OOI) is identified as the NBO which the robot aims to visit and scan. The robot then conducts fine scanning on the OOI with views determined by the NBV strategy. When the OOI is recognized as a full object, it can be replaced by its most similar 3D model in a shape database. The algorithm iterates until all of the objects are recognized and reconstructed in the scene. Various experiments and comparisons have shown the feasibility of our proposed approach.
This work aims to help the designers to make decisions in the early stage of new product development. Design concept evaluation is very critical in design process, it may affect the later stages. However, facing to uncertain circumstance, mostly, the raw data in early stage are subjective and imprecise. This work proposes a novel approach to solve this problem. The whole work is based on rough numbers, Shannon entropy, technique for order performance by similarity to ideal solution method and preference selection index method. Firstly, rough numbers and Shannon entropy are integrated to determine the weight of evaluation criteria based on their interrelationships. After that, a novel technique for order performance by similarity to ideal solution method improved by rough numbers and preference selection index method is proposed to evaluate and rank the alternatives. Then, a comparative case is carried out with proposed method and two other methods in this study. The comparation of evaluation processes indicates that the proposed method’s advantage. Compared the other methods, proposed approach is objective, simple and do not need additional input. The results of three methods are similar. It means that the proposed method is not only effective and efficient in design concept evaluation, but also can save time and cost in the early stage of new product development.
For public safety and physical security, currently more than a billion closed-circuit television (CCTV) cameras are in use around the world. Proliferation of artificial intelligence (AI) and machine/deep learning (M/DL) technologies have gained significant applications including crowd surveillance. The state-of-the-art distance and area estimation algorithms either need multiple cameras or a reference object as a ground truth. It is an open question to obtain an estimation using a single camera without a scale reference. In this paper, we propose a novel solution called E-SEC, which estimates interpersonal distance between a pair of dynamic human objects, area occupied by a dynamic crowd, and density using a single edge camera. The E-SEC framework comprises edge CCTV cameras responsible for capturing a crowd on video frames leveraging a customized YOLOv3 model for human detection. E-SEC contributes an interpersonal distance estimation algorithm vital for monitoring the social distancing of a crowd, and an area estimation algorithm for dynamically determining an area occupied by a crowd with changing size and position. A unified output module generates the crowd size, interpersonal distances, social distancing violations, area, and density per every frame. Experimental results validate the accuracy and efficiency of E-SEC with a range of different video datasets.
In this paper, a kind of multi-objective trajectory optimization method based on non-dominated sorting genetic algorithm II (NSGA-II) is proposed for free-floating space manipulator. The aim is to optimize the motion path of the space manipulator with joint angle constraints and joint velocity constraints. Firstly, the kinematics and dynamics model are built. Secondly, the 3-5-3 piecewise polynomial is selected as interpolation method for trajectory planning of joint space. Thirdly, three objective functions are established to simultaneously minimize execution time, energy consumption and jerk of the joints. At last, the objective functions are combined with the NSGA-II algorithm to get the Pareto optimal solution set. The effectiveness of the mentioned method is verified by simulations.
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