The response rates in metastatic renal cell cancer (RCC) after chemotherapy, hormonal treatment, or immunotherapy rarely exceed 15%. Recently, interferon alpha (IFN alpha) was used for treatment of this disease in several studies which also demonstrated response rates of 15%. In order to test whether IFN therapy combined with hormones would result in higher response rates we compared single agent IFN therapy with a combined therapy of rIFN alpha 2C plus medroxyprogesterone acetate (MPA) in a randomized multicenter trial. The rIFN alpha 2C (2MU) was given s.c. 5 times per week for 8-12 weeks and subsequently once weekly until week 48. In the combined treatment, 750 mg MPA was given p.o. daily until week 48 in addition to the IFN as described. The overall response rate in 93 evaluable patients was 5.4% corresponding to 2 complete and 3 partial responses. Median survival was 7 months in both treatment groups. These data confirm the ineffectivity of low IFN doses for treatment of RCC. The low response rate is not increased by addition of MPA to IFN. The analysis of other IFN studies suggests that not only IFN doses but also IFN sources may influence response rates in metastatic RCC.
Freie Vortr~ge mit Diskussionen 853 sph~rischen Bohrung jedes Plattenlochs ergibt sich eine gr5Dere Vielseitigkeit, mud durch den Wegfall des Plattenspanners kann die Freilegung des Knochens auf ein Minimum reduziert werden. Davon profitieren speziell Vorderarm-und Acetabulumbriiche. Sofern der Zugang keine Probleme stellt (z.B. am Femur) empfiehlt sich weiterhin der abnehmbare Plattenspanner. Die DCP wurde bisher bei fund 2000 Osteosynthesen unserer Kliniken angewendet. Die Erfahrungen und Resultate sind dabei sehr befriedigend.Summary. An objective and permanent record of sounds produced by the knee during movement is obtained by attaching a modified crystal microphone to the patella. The sig~lals from the microphone are filtered, amplified, and stored by a tape recorder, together with a record of the corresponding degrees of flexion. Visual interpretation of the sound recordings and preliminary computer analyses show clear differences between healthy and diseased joints.
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