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A series of novel [1,2,4]-triazolo piperidine (8), [1,2,4]-triazolo piperazine (9a-c), [1,2,4]-triazolo phenylether (10a-e), and [1,2,4]-triazolo aniline (11a-c) derivatives have been synthesized. The chemical structures of the newly synthesized compounds were characterized by IR,1H NMR,13C NMR, and LCMS. The newly synthesized compounds were screened for antimicrobial activity. Among all the compounds tested,11b(R4=4-MeO–) showed the highest activity againstStaphylococcus aureusandEscherichia coli, and9a(R1andR2=Cl) showed the highest activity againstPseudomonas aeruginosa.

Readily available quinolines (Va) and (Vb) exhibit significant in vitro cytotoxicity against human breast carcinoma cells.

are designed, synthesized, and evaluated for their in vitro antibacterial and antiproliferative activities. Compound (VIc) exhibits moderate antibacterial activity while derivatives (VIa) and (VIb) display good growth inhibition against A549 and HCT-116 carcinoma cell lines. -(RAJULU*, G. G.; BHOJYA NAIK, H. S.; VISWANADHAN, A.; THIRUVENGADAM, J.; RAJESH, K.; GANESH, S.; JAGADHESHAN, H.; KESAVAN, P. K.; Chem. Pharm. Bull. 62 (2014) 2, 168-175, http://dx.