Microwave Assisted Synthesis of Some Novel Thiopyrano[2,3-b]quinolines as a New Class of Antimicrobial Agent

Microwave Induced One-Pot Synthesis of Some New Thiopyrano[2,3-b]quinolin-2-ones under Solvent-Free Conditions

“…Hence, in continuation of our studies in the synthesis of condensed quinoline derivatives, [15][16][17][18] due to their significant biological activities, it appeared expedient to synthesize a condensed quinoline that is presented here in the present study.…”

Synthesis of thieno[2,3-b]benzo[1,8]naphthyridine-2-carboxylic acids under microwave irradiation and interaction with DNA studies

“…Hypochromism was suggested to be due to strong interactions between the electronic states of the intercalating chromophore and that of the DNA base pairs. 19 The spectral changes that we observed (hypochromicity and red shift) were consistent with the intercalation of the chromophore into the stack DNA base pairs [27][28][29][30][31] .…”

“…The results of these various binding studies have been useful in designing new and promising anticancer agents for clinical use. [18][19][20] To best of our knowledge there are no reports on the synthesis of benzo [1,8]naphthyridine under microwave irradiation by using inexpensive N-(4-methylquinolin-2-yl)acetamide as starting material. Hence, in search of an efficient method and in continuation of our work on microwave assisted organic synthesis of condensed heterocycles, [21][22][23] we have investigated a new, simple, enviro-friendly method for the preparation of benzo [1,8]naphthyridines under microwave irradiation and also reported the interaction of newly synthesized TBNC (4a) with CT-DNA.…”

Zn(OTf)2-catalyzed three component, one-pot cyclocondensation reaction of some new octahydroquinazolinone derivatives and access their bio-potential

“…Literature survey reveals that number of octahydroquinazolinone (Kantevari et al, 2006;Lin et al, 2007) derivatives have been synthesized by Biginelli reaction conditions using various aldehydes but not a single reference has been found where 2-thi(oxo)-1,2-dihydroquinoline-3-carbaldehyde is used. In view of the above observation and in continuation of our study on biologically active heterocyclic compounds (Patel et al, 2005(Patel et al, , 2008Ladani et al, 2009), We wish to report here 2-thi(oxo)-1,2-dihydroquinoline-3-carbaldehyde which is biologically active (Nandeshwarappa et al, 2006;Nityadevi et al, 2004) with a view to obtain more active heterocyclic systems containing two biologically active moieties 2-thi(oxo)-1,2-dihydroquinoline-3-carbaldehyde (Lamani et al, 2010) and octahydroquinazolinone (Abdel-Gawad et al, 2000;Minu et al, 2008).…”