ChemInform Abstract: Synthesis, Antitumor, and DNA Binding Behavior of Novel 4‐(2‐Hydroxyquinolin‐3‐yl)‐6‐phenyl‐5,6‐dihydropyrimidine Derivatives in Aqueous Medium.

Lamani, Devappa S.; Reddy, K. R. Venugopala; Naik, H. S. Bhojya; Pai, K. Sreedhara Ranganath; Kumar, Rishikesh; Fasiulla, Fasiulla; Naik, H. R. Prakash; Naik, L. R.

doi:10.1002/chin.201105158

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“…The short excitation wavelengths (maximum absorption at about 300 nm) tend to overlap extensively with many biochemical species, and a chromatographic separation step is necessary (Halliwell and Kaur, 1997). Other hydroxylated aromatic systems are also fluorescent, examples being 7-hydroxycoumarin (Maeyama et al, 1992;), 7-hydroxy-2-quinolone (Lamania et al, 2010), and 7-hydroxyphenoxazin-3-one (Zhu et al, 2010). The coumarin system has found regular use as a hydroxyl radical probe (Manevich et al, 1997; Soh et al, 2008; Louit et al, 2009; Yuan et al, 2010; Page et al 2011) or in radiation dosimetry (Collins et al, 1994; Maeyama et al, 2011), but the other systems do not appear to have been evaluated to a similar extent.…”

Section: Introductionmentioning

confidence: 99%

DNA binding hydroxyl radical probes

Tang

Konigsfeld

Aguilera

et al. 2012

Radiation Physics and Chemistry

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The hydroxyl radical is the primary mediator of DNA damage by the indirect effect of ionizing radiation. It is a powerful oxidizing agent produced by the radiolysis of water and is responsible for a significant fraction of the DNA damage associated with ionizing radiation. There is therefore an interest in the development of sensitive assays for its detection. The hydroxylation of aromatic groups to produce fluorescent products has been used for this purpose. We have examined four different chromophores which produce fluorescent products when hydroxylated. Of these, the coumarin system suffers from the fewest disadvantages. We have therefore examined its behavior when linked to a cationic peptide ligand designed to bind strongly to DNA.

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