Six marmosets (Callithrix jacchus), 20 months to 16 years old, died from a disease characterized by weakness and paralysis of the hind legs, weight lose, anemia and transient diarrhea. The lesions most prominent at necropsy were subacute to chronic tubulointerstitial nephritis, subacute to chronic pancreatitis, and generalized hemosiderosis. Chronic protein deficiency is believed to be the underlying pathogenic mechanism, since the diet contained no more than 15% animal protein during the last two years, and increasing the amount of protein was accompanied by disappearance of the syndrome.
SummaryDue to faulty use of a ch]orpyriphos-diazinon combination as a pesticide within a laboratory animal house, 19 marmosets of 2 species (Saguinus [uscicol/is and Cal/ithrix jacchus) of 98 at risk died from organophosphorous poisoning (19% mortality). The clinic a] signs were those of cholinesterase inhibitors. The morphological lesions consisted predominantly of haemorrhages in several organs, particulary the CNS, and of bone marrow necroses.
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