Chronic Tubulointerstitial Nephritis and Wasting Disease in Marmosets (Callithrix jacchus)

Brack, M.; Rothe, H.

doi:10.1177/0300985881018s0605

Cited by 47 publications

(46 citation statements)

References 18 publications

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“…) No electron-dense deposits in mesangium or capillary basement membrane by TEM Borda, Idiart, and Negrette (2000) Common marmoset (Callithrix jacchus) Mesangial IgM deposits in early infancy without histologic alterations Mesangial lesions appear at 3 months, increase between 4 and 12 months of age Early lesions consisted of symmetrical (axial) proliferation of mesangial cells and matrix Later lesions characterized by excessive mesangial matrix deposition Brack and Fooke (1991), Brack (1988), Brack (1995), Brack and Rothe (1981), Brack and Weber (1995) Baboon (Papio cynocephalus) 27/60 catheterized baboons 15 had mesangioproliferative GN with proteinuria, hypoalbuminemia, generalized edema (nephritic syndrome?) 8/10 sepsis (2/10 had septic catheter) Herellea sp., Streptococcus sp., Klebsiella sp., Staphylococcus sp., Providencia sp.…”

Section: Systemic or Generalized Drug-ada Ic Formation Associated Witmentioning

confidence: 99%

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes

et al. 2014

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Vascular inflammation, infusion reactions, glomerulopathies, and other potentially adverse effects may be observed in laboratory animals, including monkeys, on toxicity studies of therapeutic monoclonal antibodies and recombinant human protein drugs. Histopathologic and immunohistochemical (IHC) evaluation suggests these effects may be mediated by deposition of immune complexes (ICs) containing the drug, endogenous immunoglobulin, and/or complement components in the affected tissues. ICs may be observed in glomerulus, blood vessels, synovium, lung, liver, skin, eye, choroid plexus, or other tissues or bound to neutrophils, monocytes/macrophages, or platelets. IC deposition may activate complement, kinin, and/or coagulation/fibrinolytic pathways and result in a systemic proinflammatory response. IC clearance is biphasic in humans and monkeys (first from plasma to liver and/or spleen, second from liver or spleen). IC deposition/clearance is affected by IC composition, immunomodulation, and/or complement activation. Case studies are presented from toxicity study monkeys or rats and indicate IHC-IC deposition patterns similar to those predicted by experimental studies of IC-mediated reactions to heterologous protein administration to monkeys and other species. The IHC-staining patterns are consistent with findings associated with generalized and localized IC-associated pathology in humans. However, manifestations of immunogenicity in preclinical species are generally not considered predictive to humans.

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Section: Systemic or Generalized Drug-ada Ic Formation Associated Witmentioning

confidence: 99%

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes

et al. 2014

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“…Several authors have expressed the opinion that protein supplements, especially those of animal protein, might be particularly important for marmoset health (Shimwell, Warrington & Fowler, 1979;Brack & Rothe, 1981;Poole & Evans, 1982) and what little is known of the diet of S. o. oedipus in the wild suggests that it contains a considerable proportion of animal protein (16% of dry weight according to Hladik et a1. (1971)).…”

mentioning

confidence: 99%

Factors influencing population growth of a colony of cotton-top tamarins

Kirkwood

Epstein²,

Terlecki³

1983

Lab Anim

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43% of full-term births in a colony of Saguinus oedipus oedipus occurred during April and May. Interbirth interval was usually 12 months in females which reared live young and 7 months in those whose young died perinatally. 81% of all full-term births were of twins, the rest were singles. High mortality among neonates was seen with a group of bought-in animals which had been taken from their parents at an early age without participating in the rearing of siblings, and was attributable to parental incompetence. Colony management aiming to ensure that animals gain experience in caring for young before breeding is described. Mortality among all animals older than 7 days was very low. Marginal protein deficiency may have been involved in a chronic diarrhoea and weight loss syndrome seen in some animals. They recovered after addition of hard-boiled egg to the diet.

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“…[4][5][6][7]12,16,18,19 The most common types of GN include proliferative, MesPGN, and membranous GN. 19 Interstitial lesions include periglomerular lymphocytic infiltrates, focal to diffuse infiltrates of lymphocytes and plasma cells in the interstitium, and linear to diffuse fibrosis of the renal parenchyma.…”

Section: Nonhuman Primatesmentioning

confidence: 99%

“…19 Interstitial lesions include periglomerular lymphocytic infiltrates, focal to diffuse infiltrates of lymphocytes and plasma cells in the interstitium, and linear to diffuse fibrosis of the renal parenchyma. [4][5][6][7]12 However, macaques experimentally infected with simian immunodeficiency virus (SIV) appear to have a higher incidence of MesPGN or focal segmental glo- merulosclerosis (or both). 1,11 To our knowledge, this is the first report of CGN and MesPGN associated with IgA deposition in a macaque.…”

Section: Nonhuman Primatesmentioning

confidence: 99%

Immunoglobulin-A Nephropathy with Crescentic Glomerulonephritis in a Pigtailed Macaque (Macaca nemestrina)

et al. 2004

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Abstract.A 4-year-old female pigtailed macaque (Macaca nemestrina), experimentally coinfected with simian immunodeficiency virus (SIVmac251) and Mycobacterium bovis (bacillus Calmette-Guerin), was euthanatized 1 year after infection because of weight loss and labored breathing. On gross examination, both kidneys were found to be markedly enlarged (right: 54.7 g and left: 51.7 g; normal Ͻ 20 g). Renal lesions were evaluated by histopathologic, immunohistochemical, and ultrastructural methods. Light microscopy revealed that the glomeruli were diffusely hypercellular with expansion of the mesangial matrix, and crescent formation affected approximately 60% of the glomeruli. By immunohistochemical evaluation, it was found that the crescents were composed principally of macrophages, as seen by CD68 (KP1), MRP8, MAC387, and HAM56 expression. Electron microscopic examination of the glomeruli revealed extensive intramembranous, subendothelial, and mesangial electron-dense deposits and multifocal fusion of the visceral epithelial foot processes. Immunofluorescence, used to determine the composition of the electron-dense deposits, revealed diffuse granular mesangial and capillary staining for immunoglobulin A (IgA). The renal changes described in this case report are most consistent with the findings of crescentic gloerulonephritis with IgA immune complex deposition in the glomerular basement membrane and mesangium as described in humans with IgA nephropathy.

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Chronic Tubulointerstitial Nephritis and Wasting Disease in Marmosets (Callithrix jacchus)

Cited by 47 publications

References 18 publications

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes

Factors influencing population growth of a colony of cotton-top tamarins

Immunoglobulin-A Nephropathy with Crescentic Glomerulonephritis in a Pigtailed Macaque (Macaca nemestrina)

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