The prcsence of lymph n o d e metastases in patients with cervical cancer is a n important predictor of death a n d recurrence of disease. Lymph node metastases are more c o m m o n in patients with mucus-secreting carcinomas than in w o m e n with pure s q u a m o u s carcinomas e v e n i n what appears. clinically, to b e early stage disease: such neoplasms are more frequent in women u n d e r t h e a g e of 40 years. The recognition of mucus secretion in a carcinoma and the detection of vascular permeation adjacent t o t h e primary neoplasm identifies t h e patient at greatest risk of having pelvic lymph n o d e metastases.
During the course of a search for chemotherapeutic agents to be used in the treatment of tuberculosis, a considerable number of pyridine carboxylic acid derivatives were synthesized and tested (1, 2). Of these, only two compounds were found to have distinct activity, although in both instances the activity was less than that of nicotinamide itself. The two compounds were 3-aminoisonicotinic acid and its methyl ester. Unfortunately, it appeared that a high degree of specificity existed between these structures and their tuberculostatic activity so that any positional and structural deviation seemed to result in a loss of the anti-tubercular effect.With the advent of p-acetamidobenzaldehyde thiosemicarbazone (Tibione)(3, 4) as a new and reputedly clinically effective tuberculostat (5, 6, 7), another line of endeavor became available to workers in the field, and some closely related thiosemicarbazones were made and tested (8, 9), although to date most
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