Pathological prognostic indicators in cervical cancer with particular reference to patients under the age of 40 years

Buckley, C. H.; Beards, CS; Fox, H. Herbert

doi:10.1016/0020-7292(89)90777-7

Cited by 10 publications

(19 citation statements)

References 2 publications

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“…We wished to study the effect of recent improvements in histological classification, as advocated by Buckley et al (1988). They reported a higher lymph node metastasis rate in adenosquamous cancers, identified by detection of mucous secretion, compared with pure squamous cancers.…”

Section: Discussionmentioning

confidence: 99%

Cervical carcinoma in the Grampian region (1980–1991): a population‐based study of survival and cervical cytology history

Macleod

Kitchener

Parkin

et al. 1994

BJOG

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Objectives To study survival in women treated for cervical carcinoma in Grampian region, to identify clinical and pathological prognostic factors, and to correlate survival with cytology history. Design A retrospective study of all cases of cervical carcinoma using a prospectively gathered database. Data validated by 1 in 10 randomised retrospective case note sampling. Setting Aberdeen Royal Infirmary. Subjects Three hundred and sixty‐three women resident within Grampian diagnosed as having cervical carcinoma between 1980 and 1991, with five‐year survival data on the 206 diagnosed by the end of 1986. Main outcome measure Five‐year survival rates. Results The mean annual incidence of cervical carcinoma in our population was 11.2 per 100 000 women, with an overall five‐year survival of 67% in those under 40 years of age and 60% in those aged 40 years and over. On univariate analysis, survival was significantly adversely affected by tumour stage, grade and absence of previous smears. On multivariate analysis, the effect of previous smear history was lost, but stage and grade remained strong independent risk factors for survival. There was no significant difference in five‐year survival by age or tumour type. Conclusions The prognosis of cervical carcinoma in Grampian region was independently affected only by stage of disease and tumour grading and cervical smear history.

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Section: Discussionmentioning

confidence: 99%

Cervical carcinoma in the Grampian region (1980–1991): a population‐based study of survival and cervical cytology history

Macleod

Kitchener

Parkin

et al. 1994

BJOG

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“…A diagnosis of adenosquamous carcinoma was based on an admixture of both adenocarcinoma and squamous components. Mucus stains were not routinely performed to define so‐called mucus‐secreting squamous carcinoma ( 30 ) . Flow cytometric DNA analysis was performed on paraffin‐embedded tumor tissue.…”

Section: Methodsmentioning

confidence: 99%

Are adenocarcinomas and adenosquamous carcinomas different from squamous carcinomas in stage IB and II cervical cancer patients undergoing primary radical surgery?

Lai¹,

Hsueh²,

Hong³

et al. 1999

Int J Gynecol Cancer

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The aim of this study was to define clinicopathologic features and to investigate prognostic factors in early-stage cervical adenocarcinomas and adenosquamous carcinomas in patients undergoing primary radical surgery. One hundred thirty-four patients with stage IB or II cervical adenocarcinoma or adenosquamous carcinomas treated at a single institution were reviewed and compared to squamous carcinomas (N = 757) treated in the same period. Among adeno-adenosquamous carcinomas, stage II disease, parametrial extension, and deep cervical stromal invasion (>2/3) were associated with increased risk of pelvic lymph node metastases, while only clinical stage II, DNA index >1.3 (by flow cytometry), and pelvic node metastases were significantly associated with decreased survival by multivariate analyses. The five-year recurrence-free and overall survival rates of patients with adeno-adenosquamous vs squamous carcinoma were 72.2% vs 81.2% (P = 0.0109), and 74.1% vs 82.8% (P = 0.0136), respectively by Mantel-Cox test. After controlling confounding factors, histologic type (adeno-adenosquamous vs squamous) was confirmed as an independent prognostic factor for recurrence-free survival [relative risk (RR): 1.2792; 95% confidence interval (CI): 1.0628-1.5399, P = 0.0092) and overall survival (RR: 1.2594, 95% CI: 1.0467-1.5155, P = 0.0146) in the whole series (N = 891). Although pattern of relapse by histologic type was not significantly different, patients with recurrent adeno-adenosquamous carcinoma did significantly worse than those with recurrent squamous carcinoma. In conclusion, the prognosis of adeno-adenosquamous carcinoma of the cervix is slightly worse than squamous tumors. Since salvage of recurrent adeno-adenosquamous carcinoma after primary radical surgery is generally ineffective using conventional treatment, innovative strategies are necessary for the high-risk group after primary surgery and all recurrent adeno-adenosquamous carcinomas regardless of size or site.

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“…Early diagnosis is important because lymph node metastasis is one of the best predictors of poor outcome (Buckley et al , 1988; Elledge and McGuire, 1993). Paradoxically, it has been shown statistically that early diagnosis of breast cancer has not led to a substantial decrease in deaths because most of the cancers diagnosed early would not progress to be life-threatening if left untreated (Bleyer and Welch, 2012).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis of multiprobe fluorescence in situ hybridization data from tumor cell populations

Chowdhury¹,

Shackney²,

Heselmeyer‐Haddad³

et al. 2013

Bioinformatics

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Motivation: Development and progression of solid tumors can be attributed to a process of mutations, which typically includes changes in the number of copies of genes or genomic regions. Although comparisons of cells within single tumors show extensive heterogeneity, recurring features of their evolutionary process may be discerned by comparing multiple regions or cells of a tumor. A useful source of data for studying likely progression of individual tumors is fluorescence in situ hybridization (FISH), which allows one to count copy numbers of several genes in hundreds of single cells. Novel algorithms for interpreting such data phylogenetically are needed, however, to reconstruct likely evolutionary trajectories from states of single cells and facilitate analysis of tumor evolution.Results: In this article, we develop phylogenetic methods to infer likely models of tumor progression using FISH copy number data and apply them to a study of FISH data from two cancer types. Statistical analyses of topological characteristics of the tree-based model provide insights into likely tumor progression pathways consistent with the prior literature. Furthermore, tree statistics from the resulting phylogenies can be used as features for prediction methods. This results in improved accuracy, relative to unstructured gene copy number data, at predicting tumor state and future metastasis.Availability: Source code for software that does FISH tree building (FISHtrees) and the data on cervical and breast cancer examined here are available at ftp://ftp.ncbi.nlm.nih.gov/pub/FISHtrees.Contact: sachowdh@andrew.cmu.eduSupplementary information: Supplementary data are available at Bioinformatics online.

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Pathological prognostic indicators in cervical cancer with particular reference to patients under the age of 40 years

Cited by 10 publications

References 2 publications

Cervical carcinoma in the Grampian region (1980–1991): a population‐based study of survival and cervical cytology history

Cervical carcinoma in the Grampian region (1980–1991): a population‐based study of survival and cervical cytology history

Are adenocarcinomas and adenosquamous carcinomas different from squamous carcinomas in stage IB and II cervical cancer patients undergoing primary radical surgery?

Phylogenetic analysis of multiprobe fluorescence in situ hybridization data from tumor cell populations

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