Ninety-one human tumors, including various common carcinomas, low-grade malignant tumors, and benign tumors, were transplanted into athymic nude mice. Tumor take was confirmed histologically for 22 neoplasms at the initial transplantation, and 14 serially transplantable tumors were established, including some hitherto unestablished or unreported, such as lung and hepatic cell carcinomas. Among the 91 tumors were 21, 14, and 13 carcinomas of the lung, stomach, and breast, respectively. Transplantability was highest in lung carcinomas (10/21), followed by gastric carcinomas (2/14) and breast carcinomas (1/13). Morphology of original tumors was retained well in most transplanted tumors, but desmoplastic or scirrhous tumors, such as gastric and breast carcinomas, tended to become medullary with a decrease in amount of tumor stroma. The ability to produce mucin in gastric carcinomas or melanin in malignant melanoma was maintained in serially transplantable tumors. In addition, ectopic production of adrenocorticotropin and beta melanocyte-stimulating hormone continued in a transplanted small cell carcinoma of the lung. Preliminary results were obtained on hormone dependency of the transplantable breast carcinoma and on alpha1-fetoprotein in the transplantable hepatic cell carcinoma.

Polarized reflectance spectra of the organic superconductors protonated and deuterated~-(BEDT-TTF)2[Cu(NCS)2] (H and D salts) [BEDT-TTF = bis(ethylenedithio)tetrathiafulvalene] were measured over the range from 500 to 28000 cm ' at room temperature with light polarizations parallel to the crystallographic b and c axes which lie on the two-dimensional conducting plane. Polarized reflectance spectra of the organic superconductor P-(BEDT-TTF)2I3 and the organic metal P"-(BEDT-TTF)2AuBr2 were also measured in order to discuss the influence of different molecular arrangements and hydrogen-anion contacts on the electronic and vibrational properties of these salts. Frequency-dependent conductivities were calculated by a Kramers-Kronig transforrnation. By comparison of the infrared conductivity spectra of the H and D salts, the vibrational transitions induced by electronmolecular-vibration {EMV) coupling were clearly distinguished from the carbon-hydrogen bending modes of the BEDT-TTF moiety. A Drude-Lorentz dielectric function was used to evaluate the optical transport parameters and an excitation frequency of the charge-transfer {CT) band superimposed on a plasma-edge-like dispersion which was observed for each compound. The EMV-coupling energies are semiquantitatively estimated to be ca. 70 meV for both the H and D salts from the frequencies of the EMV coupling transition and the CT band in terms of the dimer charge-oscillation model. By use of the coupling energy, various parameters describing the superconducting state were evaluated and discussed on the basis of the BCS theory in a weak-coupling limit. Finally, the magnitudes of hydrogen-anion interaction were estimated from the frequency shifts of the C -H bending modes of the BEDT-TTF moiety.

ChemInform Abstract (far-IR and polarized Raman spectra (100-500 cm-1) in solvent mixtures of benzene containing Py, THF or acetone; change of the state of coordination).

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A s a h i n a , H a y a s h i . 1023 Therrnische S p a l t u n g : 3 g N o r -c a p e r a t s a u r e wurden im Olbad 7 Stdn. auf 155 -160~ erhitzt. Die so erhaltene braunliche, wachsartige Masse wurde mit Jodwasserstoffsaure 7 Stdn. im Rohr auf 1700 erhitzt, das Produkt mit Natriumthiosulfat-Losung geschuttelt und durch Zinkstaub und Salzsaure reduziert. Da die hierbei erhaltene saure Substanz immer noch amorph war, wurde sie mit der etwa 5-fachen Menge AniIin im Rohr 8 Stdn. auf gegen 220° erhitzt. Wird das jetzt neutrale Produkt aus Methanol umkrystallisiert, so liefert es Blattchen vom Schmp. 63.5-64. 50, deren Analysen-Zahlen gut auf Met h y 1-t e t r a d e c y 1 -su c cin a n i 1 stimnien. 4.593 nig Shst.: 13.175 mg CO,, 4.20 mg H,O. -4.928 mg Sbst.: 0.155 ccm ?J (zoo, 766 m m ) . -0.0109 g Shst. in 0.1014 g Campher: A = r2.j'' (nach K a s t ) .

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