Chemotherapy of human choriocarcinoma transplanted to nude mice

Chemotherapy of Human Yolk Sac Tumor Heterotransplanted in Nude Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

“…A major application of tumor marker assays has been the monitoring of clinical response of tumors to chemotherapy. A correlation between serum levels of tumor marker and tumor volume has been reported for human tumors heterotransplanted in nude mice, e.g., for AFP in the case of liver cell carcinoma (26) and for human chorionic gonadotropin in the case of choriocarcinoma (27). In the present study, a strong correlation was found between tumor volume and the AFP level in sera of mice bearing YST-l or YST-2 tumors, but no clear correlation was observed with YST -3 tumors.…”

Limitations of the human tumour xenograft system in individual patient drug sensitivity testing

“…There is an increasing body of evidence to suggest that xenografts of a particular tumour type (e.g. chorion carcinoma, Burkitt's lymphoma) are sensitive to the chemotherapeutic agents active clinically in these diseases (Povlsen & Rygaard, 1974;Hayahashi et al, 1978). There is also evidence that a xenograft line retains the same spectrum of chemosensitivity as the individual patient from whom the original tumour was obtained (Shorthouse et al, 1980;Nowak et al, 1978).…”

Efficacy of the Anticancer Agent Cisplatin in the Treatment of Human Cervical Squamous Carcinoma Xenografted in Nude Mice

“…The usefulness of the nude mouse model of human tumours for testing chemotherapeutic agents has been well documented [2][3][4][5][6][7][8]. To our knowledge only two human uterine cervical carcinoma xenografts (HeLa cell line and Yumoto strain) have been used, in separate studies [9,10] to test the chemotherapeutic drugs adriamycin, bleomycin, cyclophospha mide, mitomycin and metronidazole.…”