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31 patients received an intravenous 15-min injection of 2 g ceftriaxone at various times before abdominal or vaginal hysterectomy. Ceftriaxone concentrations in salpinges were significantly higher than in myometrium and endometrium. Tissue concentrations of 20 μg/g could be maintained for at least 5 h. Due to its high tissue concentrations maintained for the whole operative procedure, ceftriaxone does seem to be one of the antibiotics of choice for single-dose prophylaxis of postoperative infections in gynecology.

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Thirty-one patients received an intravenous bolus injection of 2 g ceftazidime over 5 min at various times before abdominal or vaginal hysterectomy. Ceftazidime concentrations in myometrium, endometrium and salpinges reached 34% to 43% of the corresponding serum levels. Subcutaneous tissue concentrations were significantly lower. Tissue concentrations of 8 mg/l were maintained for at least 5 h.